KLHL22

Gene Symbol KLHL22
Entrez Gene 84861
Alt Symbol KELCHL
Species Human
Gene Type protein-coding
Description kelch-like family member 22
Other Description kelch-like 22|kelch-like protein 22
Swissprots B7Z2G1 A8MTV3 D3DX30 A8K3Q4 Q53GT1 Q96KC6 Q96B68
Accessions EAX02961 EAX02962 EAX02963 EAX02964 Q53GT1 AK024369 AK027266 BAB55007 AK222850 BAD96570 AK290669 BAF83358 AK294682 BAH11847 BC015923 AAH15923 CR456352 CAG30238 CU013062 CAK54493 CU013350 CAK54792 DA381792 XM_011530469 XP_011528771 NM_032775 NP_116164 NR_033825
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. {ECO:0000269|PubMed:19995937, ECO:0000269|PubMed:23455478}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:23455478}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23455478}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23455478}. Note=Mainly. cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Localizes to the centrosomes shortly before cells enter anaphase After anaphase onset, predominantly associates with the polar microtubules connecting the 2 opposing centrosomes and gradually diffuses into the cytoplasm during telophase.

Human KLHL22 full length protein - ab164675 from Abcam

Category Protein
Source Wheat germ
Species Human
ab164675 on a 12.5% SDS-PAGE stained with Coomassie Blue.

KLHL22 Antibody Blocking Peptide - LS-E5631 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

KLHL22 Antibody Blocking Peptide - LS-E22195 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human KLHL22 Protein - H00084861-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

KLH22-Antibody-C-term-Blocking-Peptide - BP18159b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

KLHL22 Blocking Peptide - 33R-4051 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

Kelch-like protein 22 - H00084861-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

Kelch-like protein 22 - H00084861-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

KLHL22 fusion protein - ag9212 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human
KLHL22 fusion protein ag9212 SDS-PAGE

Recombinant Human KLHL22, GST-tagged - KLHL22-419H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Kelch-like protein 22(KLHL22) - CSB-YP684469HU CSB-EP684469HU CSB-BP684469HU CSB-MP684469HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Kelch-like protein 22 - TP304296 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
Kelch-like protein 22

KLHL22 Protein - NBP2-32606PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 µl
Species Human

KLHL22 Protein - NBP1-82238PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 µl
Species Human

KLHL22 Peptide, Human - M34GP08280H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Kelch-like protein 22 (KLHL22), Recombinant Protein - MBS1317823 from MyBioSource

Category Protein
Prices $1,430.00, $1,430.00, $1,660.00, $1,660.00, $2,420.00, $2,420.00, $2,865.00, $2,865.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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