| Gene Symbol |
CTDSPL
|
| Entrez Gene |
10217
|
| Alt Symbol |
C3orf8, HYA22, PSR1, RBSP3, SCP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
|
| Other Description |
CTD small phosphatase-like protein|CTDSP-like|NIF-like protein|NLI-interacting factor 1|RB protein serine phosphatase from chromosome 3|carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3|nuclear LIM interactor-interacting factor 1|small C-terminal domain phosphatase 3|small CTD phosphatase 3
|
| Swissprots |
Q7Z5Q2 Q3ZTU0 Q70KI4 O15194
|
| Accessions |
EAW64502 EAW64503 EAW64504 EAW64505 O15194 AI143812 AI192993 AJ575644 CAE11804 AJ575645 CAE11805 AY279532 AAP34400 AY364238 AAQ76797 BC166643 AAI66643 D88153 BAA21667 NM_001008392 NP_001008393 NM_005808 NP_005799
|
| Function |
Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. {ECO:0000250, ECO:0000269|PubMed:12721286}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Expression is restricted to non-neuronal tissues. {ECO:0000269|PubMed:15681389}.
|