Gene Symbol | CTDSPL |
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Entrez Gene | 10217 |
Alt Symbol | C3orf8, HYA22, PSR1, RBSP3, SCP3 |
Species | Human |
Gene Type | protein-coding |
Description | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like |
Other Description | CTD small phosphatase-like protein|CTDSP-like|NIF-like protein|NLI-interacting factor 1|RB protein serine phosphatase from chromosome 3|carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3|nuclear LIM interactor-interacting factor 1|small C-terminal domain phosphatase 3|small CTD phosphatase 3 |
Swissprots | Q7Z5Q2 Q3ZTU0 Q70KI4 O15194 |
Accessions | EAW64502 EAW64503 EAW64504 EAW64505 O15194 AI143812 AI192993 AJ575644 CAE11804 AJ575645 CAE11805 AY279532 AAP34400 AY364238 AAQ76797 BC166643 AAI66643 D88153 BAA21667 NM_001008392 NP_001008393 NM_005808 NP_005799 |
Function | Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. {ECO:0000250, ECO:0000269|PubMed:12721286}. |
Subcellular Location | Nucleus {ECO:0000250}. |
Tissue Specificity | Expression is restricted to non-neuronal tissues. {ECO:0000269|PubMed:15681389}. |
CTDSPL CRISPR/Cas9 KO Plasmid (h) - sc-405687 from Santa Cruz Biotechnology
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CTDSPL HDR Plasmid (h) - sc-405687-HDR from Santa Cruz Biotechnology
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CTDSPL Double Nickase Plasmid (h) - sc-405687-NIC from Santa Cruz Biotechnology
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CTDSPL Double Nickase Plasmid (h2) - sc-405687-NIC-2 from Santa Cruz Biotechnology
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CTDSPL CRISPR Activation Plasmid (h) - sc-405687-ACT from Santa Cruz Biotechnology
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CTDSPL CRISPR Activation Plasmid (h2) - sc-405687-ACT-2 from Santa Cruz Biotechnology
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CTDSPL Lentiviral Activation Particles (h) - sc-405687-LAC from Santa Cruz Biotechnology
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CTDSPL Lentiviral Activation Particles (h2) - sc-405687-LAC-2 from Santa Cruz Biotechnology
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CTDSPL siRNA (h) - sc-78502 from Santa Cruz Biotechnology
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CTDSPL shRNA Plasmid (h) - sc-78502-SH from Santa Cruz Biotechnology
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CTDSPL shRNA (h) Lentiviral Particles - sc-78502-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU007121 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0936 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0078 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0937 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0077 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0076 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6727 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6727 from Sigma-Aldrich
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CTDSPL siRNA (Human) - CRH6906 from Cohesion Biosciences
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CTDSPL - MBS8227254 from MyBioSource
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shRNA set against Human Ctdspl (NM_005808.2) - SHH271145 from Creative biogene
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shRNA set against Human CTDSPL(NM_001008392.1) - SHG205873 from Creative biogene
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shRNA set against Human CTDSPL(NM_005808.2) - SHG206119 from Creative biogene
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CTDSPL shRNA Plasmid (Human) - CHH6906 from Cohesion Biosciences
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