Gene Symbol | CTDSPL |
---|---|
Entrez Gene | 10217 |
Alt Symbol | C3orf8, HYA22, PSR1, RBSP3, SCP3 |
Species | Human |
Gene Type | protein-coding |
Description | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like |
Other Description | CTD small phosphatase-like protein|CTDSP-like|NIF-like protein|NLI-interacting factor 1|RB protein serine phosphatase from chromosome 3|carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3|nuclear LIM interactor-interacting factor 1|small C-terminal domain phosphatase 3|small CTD phosphatase 3 |
Swissprots | Q7Z5Q2 Q3ZTU0 Q70KI4 O15194 |
Accessions | EAW64502 EAW64503 EAW64504 EAW64505 O15194 AI143812 AI192993 AJ575644 CAE11804 AJ575645 CAE11805 AY279532 AAP34400 AY364238 AAQ76797 BC166643 AAI66643 D88153 BAA21667 NM_001008392 NP_001008393 NM_005808 NP_005799 |
Function | Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. {ECO:0000250, ECO:0000269|PubMed:12721286}. |
Subcellular Location | Nucleus {ECO:0000250}. |
Tissue Specificity | Expression is restricted to non-neuronal tissues. {ECO:0000269|PubMed:15681389}. |
Human CTDSPL full length protein - ab132859 from Abcam
|
||||||||||
Human CTDSPL protein fragment - ab123182 from Abcam
|
||||||||||
CTDSPL Antibody Blocking Peptide - LS-E17 from LifeSpan Bioscience
|
||||||||||
CTDSPL Antibody Blocking Peptide - LS-E26710 from LifeSpan Bioscience
|
||||||||||
CTDSPL Antibody Blocking Peptide - LS-E15552 from LifeSpan Bioscience
|
||||||||||
CTDSPL Recombinant Protein - H00010217-P01 from Novus Biologicals
|
||||||||||
Recombinant Human CTDSPL Protein - NBP1-99109 from Novus Biologicals
|
||||||||||
CTDSPL-Antibody-N-term-Blocking-peptide - BP10036a from Abgent, a WuXi AppTec company
|
||||||||||
CTDSPL blocking peptide - GTX88741-PEP from GeneTex
|
||||||||||
Human CTDSPL protein - orb168172 from Biorbyt
|
||||||||||
CTDSPL Immunizing peptide - orb17144 from Biorbyt
|
||||||||||
CTDSPL Blocking Peptide - 33R-1649 from Fitzgerald
|
||||||||||
CTDSPL protein (His tag) - 80R-2152 from Fitzgerald
|
||||||||||
CTDSPL Peptide - AC21-1549-P from Abcore
|
||||||||||
CTDSPL (82-265, His-tag) - AR50233PU-N from Acris Antibodies
|
||||||||||
CTDSPL (82-265, His-tag) - AR50233PU-S from Acris Antibodies
|
||||||||||
CTDSPL - H00010217-P01-10 from Acris Antibodies
|
||||||||||
CTDSPL - H00010217-P01-25 from Acris Antibodies
|
||||||||||
CTDSPL, 82-265aa, Human, His tag, E.coli - 01-P1408 from ARP American Research Products
|
||||||||||
CTDSPL Peptide - 46-827P from ProSci
|
||||||||||
CTDSPL Human - ENPS-576 from NeoScientific
|
||||||||||
Recombinant Human CTD Small Phosphatase-Like Enzyme - BP002705-ENZ-569 from Syd Labs
|
||||||||||
CTDSPL, 82-265aa , Human, His tag, E.coli - GWB-P0630F from Genway Biotech
|
||||||||||
Recombinant Human CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) Small Phosphatase-Like, His-tagged - CTDSPL-1922H from Creative Biomart
|
||||||||||
CTDSPL 82-265aa - CMB-1241 from Reagent Proteins
|