Gene Symbol | PIK3R5 |
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Entrez Gene | 23533 |
Alt Symbol | F730038I15Rik, FOAP-2, P101-PI3K, p101 |
Species | Human |
Gene Type | protein-coding |
Description | phosphoinositide-3-kinase, regulatory subunit 5 |
Other Description | PI3-kinase p101 subunit|phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit|phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit|phosphoinositide 3-kinase regulatory subunit 5|protein FOAP-2|ptdIns-3-kinase p101 |
Swissprots | Q8IZ23 Q5G938 D3DTS3 Q9Y2Y2 Q5G939 Q5G936 B0LPH4 Q8WYR1 |
Accessions | ABY87553 AGC09603 EAW90035 EAW90036 EAW90037 Q8WYR1 AB028925 BAB82464 AF128881 AAD33397 AK129627 AK309074 AK314186 AY725851 AAW63121 AY725852 AAW63122 AY725853 AAW63123 AY725854 AAW63124 BC028212 AAH28212 XM_005256579 XP_005256636 XM_005256580 XP_005256637 XM_011523778 XP_011522080 NM_001142633 NP_001136105 NM_001251851 NP_001238780 NM_001251852 NP_001238781 NM_001251853 NP_001238782 NM_001251855 NP_001238784 NM_014308 NP_055123 |
Function | Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli. {ECO:0000269|PubMed:15797027, ECO:0000269|PubMed:22065524}. |
Top Pathways | Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway |
PI3 Kinase p101 (D32A5) Rabbit mAb - 5569 from Cell Signaling Technology
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PI 3-kinase p101 (E-12) - sc-390916 from Santa Cruz Biotechnology
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PI 3-kinase p101 (E-14) - sc-168954 from Santa Cruz Biotechnology
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PI 3-kinase p101 (H-300) - sc-292941 from Santa Cruz Biotechnology
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PI 3-kinase p101 (I-18) - sc-130230 from Santa Cruz Biotechnology
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PI 3-kinase p101 (K-17) - sc-168955 from Santa Cruz Biotechnology
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Anti-PIK3R5 antibody - ab62792 from Abcam
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Anti-PIK3R5 antibody - ab111152 from Abcam
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Anti-PIK3R5 antibody - ab108167 from Abcam
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Anti-PIK3R5 antibody [2A3] - ab139359 from Abcam
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Anti-PIK3R5 antibody [2C6] - ab139332 from Abcam
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Anti-PIK3R5 antibody [2E4] - ab140491 from Abcam
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Anti-PIK3R5 antibody [4B11] - ab140487 from Abcam
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Anti-PIK3R5 antibody - C-terminal - ab170465 from Abcam
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Anti-PIK3R5 antibody - C-terminal - ab154043 from Abcam
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Anti-PIK3R5 Antibody - LS-C144105 from LifeSpan Bioscience
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Anti-PIK3R5 Antibody (aa695-744) - LS-C120217 from LifeSpan Bioscience
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Anti-PIK3R5 Antibody (aa110-159) - LS-C81980 from LifeSpan Bioscience
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Anti-PIK3R5 Antibody (aa471-520) - LS-C117128 from LifeSpan Bioscience
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Anti-PIK3R5 Antibody (clone D32A5) - LS-C184086 from LifeSpan Bioscience
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Anti-PIK3R5 Antibody (aa399-429, AP) - LS-C239015 from LifeSpan Bioscience
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Anti-PIK3R5 Antibody (aa399-429, APC) - LS-C239016 from LifeSpan Bioscience
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Anti-PIK3R5 Antibody (aa399-429, Biotin) - LS-C239017 from LifeSpan Bioscience
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Anti-PIK3R5 Antibody (aa399-429, FITC) - LS-C239019 from LifeSpan Bioscience
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Anti-PIK3R5 Antibody (aa399-429, PE) - LS-C239020 from LifeSpan Bioscience
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