| Gene Symbol |
PIK3R5
|
| Entrez Gene |
23533
|
| Alt Symbol |
F730038I15Rik, FOAP-2, P101-PI3K, p101
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphoinositide-3-kinase, regulatory subunit 5
|
| Other Description |
PI3-kinase p101 subunit|phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit|phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit|phosphoinositide 3-kinase regulatory subunit 5|protein FOAP-2|ptdIns-3-kinase p101
|
| Swissprots |
Q8IZ23 Q5G938 D3DTS3 Q9Y2Y2 Q5G939 Q5G936 B0LPH4 Q8WYR1
|
| Accessions |
ABY87553 AGC09603 EAW90035 EAW90036 EAW90037 Q8WYR1 AB028925 BAB82464 AF128881 AAD33397 AK129627 AK309074 AK314186 AY725851 AAW63121 AY725852 AAW63122 AY725853 AAW63123 AY725854 AAW63124 BC028212 AAH28212 XM_005256579 XP_005256636 XM_005256580 XP_005256637 XM_011523778 XP_011522080 NM_001142633 NP_001136105 NM_001251851 NP_001238780 NM_001251852 NP_001238781 NM_001251853 NP_001238782 NM_001251855 NP_001238784 NM_014308 NP_055123
|
| Function |
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli. {ECO:0000269|PubMed:15797027, ECO:0000269|PubMed:22065524}.
|
| Top Pathways |
Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway
|