Gene Symbol | PIK3R5 |
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Entrez Gene | 23533 |
Alt Symbol | F730038I15Rik, FOAP-2, P101-PI3K, p101 |
Species | Human |
Gene Type | protein-coding |
Description | phosphoinositide-3-kinase, regulatory subunit 5 |
Other Description | PI3-kinase p101 subunit|phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit|phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit|phosphoinositide 3-kinase regulatory subunit 5|protein FOAP-2|ptdIns-3-kinase p101 |
Swissprots | Q8IZ23 Q5G938 D3DTS3 Q9Y2Y2 Q5G939 Q5G936 B0LPH4 Q8WYR1 |
Accessions | ABY87553 AGC09603 EAW90035 EAW90036 EAW90037 Q8WYR1 AB028925 BAB82464 AF128881 AAD33397 AK129627 AK309074 AK314186 AY725851 AAW63121 AY725852 AAW63122 AY725853 AAW63123 AY725854 AAW63124 BC028212 AAH28212 XM_005256579 XP_005256636 XM_005256580 XP_005256637 XM_011523778 XP_011522080 NM_001142633 NP_001136105 NM_001251851 NP_001238780 NM_001251852 NP_001238781 NM_001251853 NP_001238782 NM_001251855 NP_001238784 NM_014308 NP_055123 |
Function | Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli. {ECO:0000269|PubMed:15797027, ECO:0000269|PubMed:22065524}. |
Top Pathways | Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway |
Active human PIK3CG + PIK3R5 full length protein - ab68181 from Abcam
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Human PIK3R5 full length protein - ab135013 from Abcam
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Human PIK3R5 full length protein - ab161675 from Abcam
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PIK3R5 Antibody Blocking Peptide - LS-E1059 from LifeSpan Bioscience
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PIK3R5 Antibody Blocking Peptide - LS-E9436 from LifeSpan Bioscience
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PIK3R5 Antibody Blocking Peptide - LS-E19852 from LifeSpan Bioscience
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Recombinant Human PIK3R5 Protein - H00023533-P01 from Novus Biologicals
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PIK3R5 Peptide - P3008 from Novus Biologicals
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PIK3R5-Antibody-C-term-Blocking-peptide - BP11544b from Abgent, a WuXi AppTec company
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PI3KR5-Antibody-Center-Blocking-Peptide - BP8027c from Abgent, a WuXi AppTec company
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Human PIK3R5 protein - orb246267 from Biorbyt
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PIK3R5 Blocking Peptide - 33R-8741 from Fitzgerald
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PIK3R5 Blocking Peptide - 33R-3839 from Fitzgerald
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PIK3R5 - H00023533-P01 from Acris Antibodies
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PIK3R5 fusion protein - ag4137 from Proteintech Group
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PIK3R5 fusion protein - ag17678 from Proteintech Group
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Recombinant Human Human PIK3CG, His-tagged - PIK3R5-31760TH from Creative Biomart
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Recombinant human Phosphoinositide 3-kinase regulatory subunit 5 - CSB-EP841225HU CSB-BP841225HU CSB-MP841225HU from Cusabio
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Recombinant human Phosphoinositide 3-kinase regulatory subunit 5 - CSB-YP841225HU from Cusabio
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Recombinant Human Phosphoinositide 3-kinase regulatory subunit 5(PIK3R5) ,partia - CSB-YP841225HU CSB-EP841225HU CSB-BP841225HU CSB-MP841225HU from Cusabio
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Phosphoinositide 3-kinase regulatory subunit 5, Recombinant Protein - MBS1423596 from MyBioSource
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Phosphoinositide 3 Kinase, p101, aa8-19, aa838-849, Peptide - MBS659288 from MyBioSource
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PIK3R5 Recombinant Protein Antigen - NBP2-49037PEP from Novus Biologicals
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PIK3R5 Peptide, Human - M34GP11792H from Creative Peptides
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PIK3R5 Recombinant Protein (OPCA02392) - OPCA02392 from Aviva Systems Biology
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