PIK3R5
| Gene Symbol | PIK3R5 |
|---|---|
| Entrez Gene | 23533 |
| Alt Symbol | F730038I15Rik, FOAP-2, P101-PI3K, p101 |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphoinositide-3-kinase, regulatory subunit 5 |
| Other Description | PI3-kinase p101 subunit|phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit|phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit|phosphoinositide 3-kinase regulatory subunit 5|protein FOAP-2|ptdIns-3-kinase p101 |
| Swissprots | Q8IZ23 Q5G938 D3DTS3 Q9Y2Y2 Q5G939 Q5G936 B0LPH4 Q8WYR1 |
| Accessions | ABY87553 AGC09603 EAW90035 EAW90036 EAW90037 Q8WYR1 AB028925 BAB82464 AF128881 AAD33397 AK129627 AK309074 AK314186 AY725851 AAW63121 AY725852 AAW63122 AY725853 AAW63123 AY725854 AAW63124 BC028212 AAH28212 XM_005256579 XP_005256636 XM_005256580 XP_005256637 XM_011523778 XP_011522080 NM_001142633 NP_001136105 NM_001251851 NP_001238780 NM_001251852 NP_001238781 NM_001251853 NP_001238782 NM_001251855 NP_001238784 NM_014308 NP_055123 |
| Function | Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Tissue Specificity | Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli. {ECO:0000269|PubMed:15797027, ECO:0000269|PubMed:22065524}. |
| Top Pathways | Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway |
PI 3-kinase p101 CRISPR/Cas9 KO Plasmid (h) - sc-405959 from Santa Cruz Biotechnology
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PI 3-kinase p101 HDR Plasmid (h) - sc-405959-HDR from Santa Cruz Biotechnology
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PI 3-kinase p101 Double Nickase Plasmid (h) - sc-405959-NIC from Santa Cruz Biotechnology
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PI 3-kinase p101 Double Nickase Plasmid (h2) - sc-405959-NIC-2 from Santa Cruz Biotechnology
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PI 3-kinase p101 CRISPR Activation Plasmid (h) - sc-405959-ACT from Santa Cruz Biotechnology
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PI 3-kinase p101 CRISPR Activation Plasmid (h2) - sc-405959-ACT-2 from Santa Cruz Biotechnology
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PI 3-kinase p101 Lentiviral Activation Particles (h) - sc-405959-LAC from Santa Cruz Biotechnology
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PI 3-kinase p101 Lentiviral Activation Particles (h2) - sc-405959-LAC-2 from Santa Cruz Biotechnology
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PI 3-kinase p101 siRNA (h) - sc-94221 from Santa Cruz Biotechnology
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PI 3-kinase p101 shRNA Plasmid (h) - sc-94221-SH from Santa Cruz Biotechnology
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PI 3-kinase p101 shRNA (h) Lentiviral Particles - sc-94221-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU032151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16813 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16813 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04096 from Sigma-Aldrich
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PIK3R5 siRNA (Human) - CRH8338 from Cohesion Biosciences
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PIK3R5 RNAi - H00023533-R02 from Novus Biologicals
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shRNA set against Human PIK3R5 (NM_014308.3) - SHH375820 from Creative biogene
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Human PIK3R5 siRNA - orb268840 from Biorbyt
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PIK3R5 shRNA Plasmid (Human) - CHH8338 from Cohesion Biosciences
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PIK3R5 miRNA 3'UTR clone - MiUTR3H-11790 from Creative biogene
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PIK3R5 miRNA 3'UTR clone - MiUTR3H-11791 from Creative biogene
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