| Gene Symbol |
ACOT13
|
| Entrez Gene |
55856
|
| Alt Symbol |
HT012, PNAS-27, THEM2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acyl-CoA thioesterase 13
|
| Other Description |
acyl-coenzyme A thioesterase 13|hypothalamus protein HT012|thioesterase superfamily member 2
|
| Swissprots |
Q9NPJ3 O95549 F5H2L4
|
| Accessions |
CAI93515 EAW55460 Q9NPJ3 AF155649 AAF67006 AF220186 AAF67651 AF274952 AAK07529 AK000508 BAA91215 AK309738 BC000894 AAH00894 BG568305 CB852340 DB214267 NM_001160094 NP_001153566 NM_018473 NP_060943
|
| Function |
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin (By similarity). {ECO:0000250}.
|
