Gene Symbol | ACOT13 |
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Entrez Gene | 55856 |
Alt Symbol | HT012, PNAS-27, THEM2 |
Species | Human |
Gene Type | protein-coding |
Description | acyl-CoA thioesterase 13 |
Other Description | acyl-coenzyme A thioesterase 13|hypothalamus protein HT012|thioesterase superfamily member 2 |
Swissprots | Q9NPJ3 O95549 F5H2L4 |
Accessions | CAI93515 EAW55460 Q9NPJ3 AF155649 AAF67006 AF220186 AAF67651 AF274952 AAK07529 AK000508 BAA91215 AK309738 BC000894 AAH00894 BG568305 CB852340 DB214267 NM_001160094 NP_001153566 NM_018473 NP_060943 |
Function | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin (By similarity). {ECO:0000250}. |
THEM2 CRISPR/Cas9 KO Plasmid (h) - sc-407136 from Santa Cruz Biotechnology
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THEM2 HDR Plasmid (h) - sc-407136-HDR from Santa Cruz Biotechnology
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THEM2 Double Nickase Plasmid (h) - sc-407136-NIC from Santa Cruz Biotechnology
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THEM2 Double Nickase Plasmid (h2) - sc-407136-NIC-2 from Santa Cruz Biotechnology
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THEM2 CRISPR Activation Plasmid (h) - sc-407136-ACT from Santa Cruz Biotechnology
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THEM2 CRISPR Activation Plasmid (h2) - sc-407136-ACT-2 from Santa Cruz Biotechnology
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THEM2 Lentiviral Activation Particles (h) - sc-407136-LAC from Santa Cruz Biotechnology
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THEM2 Lentiviral Activation Particles (h2) - sc-407136-LAC-2 from Santa Cruz Biotechnology
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THEM2 siRNA (h) - sc-95646 from Santa Cruz Biotechnology
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THEM2 shRNA Plasmid (h) - sc-95646-SH from Santa Cruz Biotechnology
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THEM2 shRNA (h) Lentiviral Particles - sc-95646-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU137181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2727 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2727 from Sigma-Aldrich
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ACOT13 siRNA (Human) - CRJ0974 from Cohesion Biosciences
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ACOT13 - MBS8207076 from MyBioSource
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shRNA set against Human ACOT13 (NM_018473.3) - SHH230402 from Creative biogene
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Human ACOT13 siRNA - orb271475 from Biorbyt
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ACOT13 shRNA Plasmid (Human) - CHJ0974 from Cohesion Biosciences
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ACOT13 miRNA 3'UTR clone - MiUTR4H-TG00090 from Creative biogene
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