| Gene Symbol | ACOT13 |
|---|---|
| Entrez Gene | 55856 |
| Alt Symbol | HT012, PNAS-27, THEM2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | acyl-CoA thioesterase 13 |
| Other Description | acyl-coenzyme A thioesterase 13|hypothalamus protein HT012|thioesterase superfamily member 2 |
| Swissprots | Q9NPJ3 O95549 F5H2L4 |
| Accessions | CAI93515 EAW55460 Q9NPJ3 AF155649 AAF67006 AF220186 AAF67651 AF274952 AAK07529 AK000508 BAA91215 AK309738 BC000894 AAH00894 BG568305 CB852340 DB214267 NM_001160094 NP_001153566 NM_018473 NP_060943 |
| Function | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin (By similarity). {ECO:0000250}. |