| Gene Symbol |
Hhex
|
| Entrez Gene |
15242
|
| Alt Symbol |
Hex, Hex1, Hhex-rs2, Prh, Prhx
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
hematopoietically expressed homeobox
|
| Other Description |
hematopoietically expressed homeobox, related sequence 2|hematopoietically-expressed homeobox protein Hhex|homeobox protein HEX|homeobox protein PRH|mHex
|
| Swissprots |
P43120 Q9R1X2 Q9CRV1 Q544N6
|
| Accessions |
AAF04349 BAA76714 CAA79729 EDL41790 P43120 AK014111 BAB29163 AK033664 BAC28416 AK149553 BC057986 AAH57986 NM_008245 NP_032271
|
| Function |
Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL. {ECO:0000250, ECO:0000269|PubMed:10804173, ECO:0000269|PubMed:16936074}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Top Pathways |
Maturity onset diabetes of the young, Transcriptional misregulation in cancer
|