Gene Symbol | Hhex |
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Entrez Gene | 15242 |
Alt Symbol | Hex, Hex1, Hhex-rs2, Prh, Prhx |
Species | Mouse |
Gene Type | protein-coding |
Description | hematopoietically expressed homeobox |
Other Description | hematopoietically expressed homeobox, related sequence 2|hematopoietically-expressed homeobox protein Hhex|homeobox protein HEX|homeobox protein PRH|mHex |
Swissprots | P43120 Q9R1X2 Q9CRV1 Q544N6 |
Accessions | AAF04349 BAA76714 CAA79729 EDL41790 P43120 AK014111 BAB29163 AK033664 BAC28416 AK149553 BC057986 AAH57986 NM_008245 NP_032271 |
Function | Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL. {ECO:0000250, ECO:0000269|PubMed:10804173, ECO:0000269|PubMed:16936074}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Top Pathways | Maturity onset diabetes of the young, Transcriptional misregulation in cancer |
Hex CRISPR/Cas9 KO Plasmid (m) - sc-420852 from Santa Cruz Biotechnology
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Hex HDR Plasmid (m) - sc-420852-HDR from Santa Cruz Biotechnology
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Hex Double Nickase Plasmid (m) - sc-420852-NIC from Santa Cruz Biotechnology
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Hex Double Nickase Plasmid (m2) - sc-420852-NIC-2 from Santa Cruz Biotechnology
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Hex CRISPR Activation Plasmid (m) - sc-420852-ACT from Santa Cruz Biotechnology
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Hex CRISPR Activation Plasmid (m2) - sc-420852-ACT-2 from Santa Cruz Biotechnology
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Hex Lentiviral Activation Particles (m) - sc-420852-LAC from Santa Cruz Biotechnology
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Hex Lentiviral Activation Particles (m2) - sc-420852-LAC-2 from Santa Cruz Biotechnology
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Hex siRNA (m) - sc-61862 from Santa Cruz Biotechnology
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Hex shRNA Plasmid (m) - sc-61862-SH from Santa Cruz Biotechnology
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Hex shRNA (m) Lentiviral Particles - sc-61862-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU001191 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN33217 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33217 from Sigma-Aldrich
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HHEX siRNA (Mouse) - CRM1825 from Cohesion Biosciences
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HHEX - MBS8230435 from MyBioSource
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shRNA set against Mouse HHEX (NM_008245.3) - SHH311981 from Creative biogene
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shRNA set against Mouse Hhex(NM_008245.3) - SHH120089 from Creative biogene
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Mouse HHEX siRNA - orb281301 from Biorbyt
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HHEX shRNA Plasmid (Mouse) - CHM1825 from Cohesion Biosciences
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HHEX miRNA 3'UTR clone - MiUTR1M-05613 from Creative biogene
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