Gene Symbol | Hhex |
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Entrez Gene | 15242 |
Alt Symbol | Hex, Hex1, Hhex-rs2, Prh, Prhx |
Species | Mouse |
Gene Type | protein-coding |
Description | hematopoietically expressed homeobox |
Other Description | hematopoietically expressed homeobox, related sequence 2|hematopoietically-expressed homeobox protein Hhex|homeobox protein HEX|homeobox protein PRH|mHex |
Swissprots | P43120 Q9R1X2 Q9CRV1 Q544N6 |
Accessions | AAF04349 BAA76714 CAA79729 EDL41790 P43120 AK014111 BAB29163 AK033664 BAC28416 AK149553 BC057986 AAH57986 NM_008245 NP_032271 |
Function | Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL. {ECO:0000250, ECO:0000269|PubMed:10804173, ECO:0000269|PubMed:16936074}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Top Pathways | Maturity onset diabetes of the young, Transcriptional misregulation in cancer |
Recombinant Mouse Hematopoietically-expressed homeobox protein Hhex(Hhex) - CSB-YP010335MO CSB-EP010335MO CSB-BP010335MO CSB-MP010335MO from Cusabio
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Recombinant Mouse HHEX Protein - HHEX-7611M from Creative Biomart
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Hematopoietically-expressed homeobox protein Hhex (Hhex), Recombinant Protein - MBS962362 from MyBioSource
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