PNPLA6

Gene Symbol	PNPLA6
Entrez Gene	10908
Alt Symbol	BNHS, LNMS, NTE, NTEMND, OMCS, SPG39, iPLA2delta, sws
Species	Human
Gene Type	protein-coding
Description	patatin-like phospholipase domain containing 6
Other Description	neuropathy target esterase|patatin-like phospholipase domain-containing protein 6
Swissprots	F5H5K9 Q9UG58 O60859 B7Z7T2 Q8IY17 B4DFB9 A6NGQ0 Q86W58 J3KQS3
Accessions	AIL88793 AIL88794 AIL88795 AIL88796 AIL88797 AIL88798 AIL88799 EAW69029 EAW69030 Q8IY17 AJ004832 CAA06164 AK293807 BAG57214 AK294021 BAG57380 AK302462 BAH13718 AL050362 CAB43674 BC038229 AAH38229 BC050553 AAH50553 BC051768 AAH51768 BQ001677 BQ430066 DA096881 DA104284 DA247219 DB068563 NM_001166111 NP_001159583 NM_001166112 NP_001159584 NM_001166113 NP_001159585 NM_001166114 NP_001159586 NM_006702 NP_006693
Function	Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. {ECO:0000269|PubMed:15044461, ECO:0000269|PubMed:1666291}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:15044461}; Single-pass type I membrane protein {ECO:0000269|PubMed:15044461}; Cytoplasmic side {ECO:0000269|PubMed:15044461}. Note=Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment.
Tissue Specificity	Expressed in brain, placenta, kidney, neuron and skeletal muscle. {ECO:0000269|PubMed:9576844}.
Top Pathways	Glycerophospholipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NTE (G-4) - sc-271049 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

NTE (K-19) - sc-30587 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

NTE (H-200) - sc-48739 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

NTE (C-20) - sc-30588 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-NTE antibody - ab77153 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-NTE antibody - ab110391 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PNPLA6 / NTE Antibody (aa496-510) - LS-C108892 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-PNPLA6 / NTE Antibody (aa1323-1348) - LS-C122327 from LifeSpan Bioscience Prices $405.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PNPLA6 / NTE Antibody (C-Terminus, Sepharose) - LS-C172021 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PNPLA6 / NTE Antibody (C-Terminus, Magnetic beads) - LS-C172020 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PNPLA6 / NTE Antibody (aa1000-1029, AP) - LS-C266662 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PNPLA6 / NTE Antibody (aa1000-1029, APC) - LS-C266663 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PNPLA6 / NTE Antibody (aa1000-1029, Biotin) - LS-C266664 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PNPLA6 / NTE Antibody (aa1000-1029, FITC) - LS-C266665 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PNPLA6 / NTE Antibody (aa1000-1029, PE) - LS-C266667 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PNPLA6 / NTE Antibody (aa1000-1029, Azide-free, HRP) - LS-C266666 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PNPLA6 / NTE Antibody (aa960-990) - LS-C324144 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PNPLA6 / NTE Antibody (C-Terminus) - LS-C135198 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PNPLA6 / NTE Antibody (C-Terminus) - LS-C172019 from LifeSpan Bioscience Prices $295.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PNPLA6 / NTE Antibody (aa1000-1029) - LS-C163827 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PNPLA6 / NTE Antibody (clone 3D10) - LS-C134033 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3D10

PNPLA6 Antibody - NBP1-74214 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

PNPLA6 Antibody (3D10) - H00010908-M08 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3D10

PNPLA6 Antibody - NBP1-80984 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PNPLA6 Antibody - NBP1-46109 from Novus Biologicals Prices $229.00 Sizes 100 µg Host Goat Clonality Polyclonal

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