PNPLA6

Gene Symbol PNPLA6
Entrez Gene 10908
Alt Symbol BNHS, LNMS, NTE, NTEMND, OMCS, SPG39, iPLA2delta, sws
Species Human
Gene Type protein-coding
Description patatin-like phospholipase domain containing 6
Other Description neuropathy target esterase|patatin-like phospholipase domain-containing protein 6
Swissprots F5H5K9 Q9UG58 O60859 B7Z7T2 Q8IY17 B4DFB9 A6NGQ0 Q86W58 J3KQS3
Accessions AIL88793 AIL88794 AIL88795 AIL88796 AIL88797 AIL88798 AIL88799 EAW69029 EAW69030 Q8IY17 AJ004832 CAA06164 AK293807 BAG57214 AK294021 BAG57380 AK302462 BAH13718 AL050362 CAB43674 BC038229 AAH38229 BC050553 AAH50553 BC051768 AAH51768 BQ001677 BQ430066 DA096881 DA104284 DA247219 DB068563 NM_001166111 NP_001159583 NM_001166112 NP_001159584 NM_001166113 NP_001159585 NM_001166114 NP_001159586 NM_006702 NP_006693
Function Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. {ECO:0000269|PubMed:15044461, ECO:0000269|PubMed:1666291}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:15044461}; Single-pass type I membrane protein {ECO:0000269|PubMed:15044461}; Cytoplasmic side {ECO:0000269|PubMed:15044461}. Note=Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment.
Tissue Specificity Expressed in brain, placenta, kidney, neuron and skeletal muscle. {ECO:0000269|PubMed:9576844}.
Top Pathways Glycerophospholipid metabolism

PNPLA6 overexpression lysate - LY431706 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

NTE (h2): 293T Lysate - sc-116250 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

PNPLA6 Overexpression Lysate (Native) - NBP2-10163 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: PNPLA6 Overexpression Lysate (Adult Normal) [NBP2-10163] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PNPLA6.

Panoply™ Human PNPLA6 Knockdown Stable Cell Line - CSC-DC012041 from Creative biogene

Category Cell Line
Species Human
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