PNPLA6

Gene Symbol	PNPLA6
Entrez Gene	10908
Alt Symbol	BNHS, LNMS, NTE, NTEMND, OMCS, SPG39, iPLA2delta, sws
Species	Human
Gene Type	protein-coding
Description	patatin-like phospholipase domain containing 6
Other Description	neuropathy target esterase|patatin-like phospholipase domain-containing protein 6
Swissprots	F5H5K9 Q9UG58 O60859 B7Z7T2 Q8IY17 B4DFB9 A6NGQ0 Q86W58 J3KQS3
Accessions	AIL88793 AIL88794 AIL88795 AIL88796 AIL88797 AIL88798 AIL88799 EAW69029 EAW69030 Q8IY17 AJ004832 CAA06164 AK293807 BAG57214 AK294021 BAG57380 AK302462 BAH13718 AL050362 CAB43674 BC038229 AAH38229 BC050553 AAH50553 BC051768 AAH51768 BQ001677 BQ430066 DA096881 DA104284 DA247219 DB068563 NM_001166111 NP_001159583 NM_001166112 NP_001159584 NM_001166113 NP_001159585 NM_001166114 NP_001159586 NM_006702 NP_006693
Function	Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. {ECO:0000269|PubMed:15044461, ECO:0000269|PubMed:1666291}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:15044461}; Single-pass type I membrane protein {ECO:0000269|PubMed:15044461}; Cytoplasmic side {ECO:0000269|PubMed:15044461}. Note=Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment.
Tissue Specificity	Expressed in brain, placenta, kidney, neuron and skeletal muscle. {ECO:0000269|PubMed:9576844}.
Top Pathways	Glycerophospholipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat PNPLA6 / NTE ELISA Kit (Sandwich ELISA) - LS-F7187 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.057 ng/ml Range 0.156-10 ng/ml

Human PNPLA6 / NTE ELISA Kit (Sandwich ELISA) - LS-F12353 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Neuropathy target esterase, PNPLA6, Human, ELISA Kit - E2147h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Neuropathy Target Esterase, ELISA Kit - MBS096000 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Neuropathy Target Esterase, ELISA Kit - MBS055085 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Neuropathy Target Esterase, ELISA Kit - MBS089444 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Neuropathy Target Esterase, ELISA Kit - MBS097145 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Neuropathy Target Esterase, ELISA Kit - MBS053115 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml Range 0.25ng/ml-8ng/ml

Neuropathy Target Esterase, ELISA Kit - MBS055428 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Neuropathy Target Esterase, ELISA Kit - MBS074462 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Neuropathy Target Esterase (NTE), ELISA Kit - MBS2019458 from MyBioSource Category ELISA Kit Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.057ng/mL. Range 0.156-10ng/mL

patatin-like phospholipase domain containing 6, ELISA Kit - MBS706807 from MyBioSource Category ELISA Kit Prices $550.00, $795.00, $2,890.00, $5,465.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of chicken PNPLA6 is typically less than 7.8 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 31.25 pg/ml -2000 pg/ml.

ELISA Kit for Neuropathy Target Esterase (NTE) - SEH515Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse PNPLA6 / NTE ELISA Kit (Custom ELISA) - LS-F19361 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human Neuropathy target esterase ELISA Kit - abx251462 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human Neuropathy target esterase ELISA Kit - EKE54123 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 21 pg/mL Range 0.156-10 ng/mL

PNPLA6 - EKH4256 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

PNPLA6 ELISA Kit (Human) (OKEH01525) - OKEH01525 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.051 ng/mL Range 0.156 - 10 ng/mL

Human PNPLA6 ELISA Kit - E026290 from Biobool Category ELISA Kit Sensitivity <0.094ng/ml

Human NTE ELISA Kit - E026291 from Biobool Category ELISA Kit

NTE ELISA Kit (Rat) (OKDD00691) - OKDD00691 from Aviva Systems Biology Category ELISA Kit Prices $615.00 Sizes 96 wells Sensitivity <0.057 ng/mL Range 0.156-10 ng/mL

Human Neuropathy target esterase ELISA Kit - EK4332 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Range 0.312-20 ng/mL

Neuropathy target esterase, ELISA Kit - MBS2885910 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.156-10 ng/mL

Neuropathy target esterase, ELISA Kit - MBS760154 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Neuropathy target esterase, ELISA Kit - MBS9428158 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 21 pg/mL Range 0.156-10 ng/mL

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