PNPLA6

Gene Symbol PNPLA6
Entrez Gene 10908
Alt Symbol BNHS, LNMS, NTE, NTEMND, OMCS, SPG39, iPLA2delta, sws
Species Human
Gene Type protein-coding
Description patatin-like phospholipase domain containing 6
Other Description neuropathy target esterase|patatin-like phospholipase domain-containing protein 6
Swissprots F5H5K9 Q9UG58 O60859 B7Z7T2 Q8IY17 B4DFB9 A6NGQ0 Q86W58 J3KQS3
Accessions AIL88793 AIL88794 AIL88795 AIL88796 AIL88797 AIL88798 AIL88799 EAW69029 EAW69030 Q8IY17 AJ004832 CAA06164 AK293807 BAG57214 AK294021 BAG57380 AK302462 BAH13718 AL050362 CAB43674 BC038229 AAH38229 BC050553 AAH50553 BC051768 AAH51768 BQ001677 BQ430066 DA096881 DA104284 DA247219 DB068563 NM_001166111 NP_001159583 NM_001166112 NP_001159584 NM_001166113 NP_001159585 NM_001166114 NP_001159586 NM_006702 NP_006693
Function Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. {ECO:0000269|PubMed:15044461, ECO:0000269|PubMed:1666291}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:15044461}; Single-pass type I membrane protein {ECO:0000269|PubMed:15044461}; Cytoplasmic side {ECO:0000269|PubMed:15044461}. Note=Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment.
Tissue Specificity Expressed in brain, placenta, kidney, neuron and skeletal muscle. {ECO:0000269|PubMed:9576844}.
Top Pathways Glycerophospholipid metabolism

NTE CRISPR/Cas9 KO Plasmid (h) - sc-406850 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NTE HDR Plasmid (h) - sc-406850-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NTE Double Nickase Plasmid (h) - sc-406850-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NTE Double Nickase Plasmid (h2) - sc-406850-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NTE CRISPR Activation Plasmid (h) - sc-406850-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NTE CRISPR Activation Plasmid (h2) - sc-406850-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NTE Lentiviral Activation Particles (h) - sc-406850-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NTE Lentiviral Activation Particles (h2) - sc-406850-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NTE siRNA (h) - sc-44513 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NTE shRNA Plasmid (h) - sc-44513-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NTE shRNA (h) Lentiviral Particles - sc-44513-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU057391 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17067 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17067 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01026 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01026

PNPLA6 siRNA (Human) - CRH7437 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PNPLA6 (NM_006702.4) - SHH378828 from Creative biogene

Category siRNA
Species Reactivities Human

Human PNPLA6 siRNA - orb267939 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PNPLA6 shRNA Plasmid (Human) - CHH7437 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PNPLA6 miRNA 3'UTR clone - MiUTR3H-05769 from Creative biogene

Species Reactivities Human

PNPLA6 miRNA 3'UTR clone - MiUTR3H-05770 from Creative biogene

Species Reactivities Human

PNPLA6 miRNA 3'UTR clone - MiUTR3H-05771 from Creative biogene

Species Reactivities Human

PNPLA6 miRNA 3'UTR clone - MiUTR3H-05772 from Creative biogene

Species Reactivities Human

PNPLA6 miRNA 3'UTR clone - MiUTR3H-05773 from Creative biogene

Species Reactivities Human
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