SNX6

Gene Symbol	SNX6
Entrez Gene	58533
Alt Symbol	MSTP010, TFAF2
Species	Human
Gene Type	protein-coding
Description	sorting nexin 6
Other Description	TRAF4-associated factor 2|sorting nexin-6|tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2
Swissprots	C0H5W9 Q9UNH7 Q9Y449
Accessions	EAW65913 EAW65914 EAW65915 EAW65916 EAW65917 EAW65918 Q9UNH7 AF109364 AAQ13512 AF121856 AAD27829 AK021456 BAG51034 AK124315 AK292250 BAF84939 AK296213 BAG58939 AK308464 BC001798 AAH01798 BG722853 BI870378 JF432480 ADZ15697 U83194 AAD24202 XM_006720224 XP_006720287 NM_152233 NP_689419 NM_021249 NP_067072
Function	Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142).
Subcellular Location	Early endosome {ECO:0000269|PubMed:11485546, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774}. Early endosome membrane {ECO:0000269|PubMed:19935774, ECO:0000303|PubMed:11485546}; Peripheral membrane protein {ECO:0000269|PubMed:11485546}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:20354142}. Cytoplasm {ECO:0000269|PubMed:20830743}. Nucleus {ECO:0000269|PubMed:11591366, ECO:0000269|PubMed:20830743}. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes (PubMed:19935774). Only a minor proportion is seen in the nucleus. {ECO:0000269|PubMed:19935774}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SNX6 (D-1) - sc-365795 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

SNX6 (D-5) - sc-365965 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

SNX6 (K-18) - sc-5260 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SNX6 (H-40) - sc-50373 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

SNX6 (N-19) - sc-8679 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Snx6 antibody - ab135761 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SNX6 Antibody (aa312-361) - LS-C151930 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SNX6 Antibody (clone 335CT6.4.6, AP) - LS-C250420 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 335CT6.4.6

Anti-SNX6 Antibody (clone 335CT6.4.6, APC) - LS-C250421 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 335CT6.4.6

Anti-SNX6 Antibody - LS-C161376 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SNX6 Antibody (N-Terminus, PE) - LS-C282844 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX6 Antibody (N-Terminus, FITC) - LS-C282845 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX6 Antibody (clone 335CT6.4.6) - LS-C319203 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 335CT6.4.6

Anti-SNX6 Antibody (clone 335CT6.4.6, Biotin) - LS-C250422 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 335CT6.4.6

Anti-SNX6 Antibody (clone 335CT6.4.6, FITC) - LS-C250423 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 335CT6.4.6

Anti-SNX6 Antibody (clone 335CT6.4.6, Azide-free, HRP) - LS-C250424 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 335CT6.4.6

Anti-SNX6 Antibody (aa81-110) - LS-C98200 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SNX6 Antibody (AP) - LS-C282833 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX6 Antibody (clone 335CT6.4.6, PE) - LS-C250425 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 335CT6.4.6

Anti-SNX6 Antibody (Biotin) - LS-C282834 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX6 Antibody - LS-C161375 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Mouse Clonality Monoclonal

Anti-SNX6 Antibody (APC) - LS-C282835 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX6 Antibody (N-Terminus, AP) - LS-C282840 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX6 Antibody (FITC) - LS-C282837 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SNX6 Antibody (Azide-free, HRP) - LS-C282838 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Search more