| Gene Symbol |
SNX6
|
| Entrez Gene |
58533
|
| Alt Symbol |
MSTP010, TFAF2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sorting nexin 6
|
| Other Description |
TRAF4-associated factor 2|sorting nexin-6|tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2
|
| Swissprots |
C0H5W9 Q9UNH7 Q9Y449
|
| Accessions |
EAW65913 EAW65914 EAW65915 EAW65916 EAW65917 EAW65918 Q9UNH7 AF109364 AAQ13512 AF121856 AAD27829 AK021456 BAG51034 AK124315 AK292250 BAF84939 AK296213 BAG58939 AK308464 BC001798 AAH01798 BG722853 BI870378 JF432480 ADZ15697 U83194 AAD24202 XM_006720224 XP_006720287 NM_152233 NP_689419 NM_021249 NP_067072
|
| Function |
Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142).
|
| Subcellular Location |
Early endosome {ECO:0000269|PubMed:11485546, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774}. Early endosome membrane {ECO:0000269|PubMed:19935774, ECO:0000303|PubMed:11485546}; Peripheral membrane protein {ECO:0000269|PubMed:11485546}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:20354142}. Cytoplasm {ECO:0000269|PubMed:20830743}. Nucleus {ECO:0000269|PubMed:11591366, ECO:0000269|PubMed:20830743}. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes (PubMed:19935774). Only a minor proportion is seen in the nucleus. {ECO:0000269|PubMed:19935774}.
|