SNX6

Gene Symbol SNX6
Entrez Gene 58533
Alt Symbol MSTP010, TFAF2
Species Human
Gene Type protein-coding
Description sorting nexin 6
Other Description TRAF4-associated factor 2|sorting nexin-6|tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2
Swissprots C0H5W9 Q9UNH7 Q9Y449
Accessions EAW65913 EAW65914 EAW65915 EAW65916 EAW65917 EAW65918 Q9UNH7 AF109364 AAQ13512 AF121856 AAD27829 AK021456 BAG51034 AK124315 AK292250 BAF84939 AK296213 BAG58939 AK308464 BC001798 AAH01798 BG722853 BI870378 JF432480 ADZ15697 U83194 AAD24202 XM_006720224 XP_006720287 NM_152233 NP_689419 NM_021249 NP_067072
Function Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142).
Subcellular Location Early endosome {ECO:0000269|PubMed:11485546, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774}. Early endosome membrane {ECO:0000269|PubMed:19935774, ECO:0000303|PubMed:11485546}; Peripheral membrane protein {ECO:0000269|PubMed:11485546}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:20354142}. Cytoplasm {ECO:0000269|PubMed:20830743}. Nucleus {ECO:0000269|PubMed:11591366, ECO:0000269|PubMed:20830743}. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes (PubMed:19935774). Only a minor proportion is seen in the nucleus. {ECO:0000269|PubMed:19935774}.

SNX6-Over-expression-Lysate - LY11163a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag SNX6 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SNX6 gene

SNX6 293 Cell Lysate - 402489 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Snx6 Overexpression Lysate (Native) - NBL1-16320 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Snx6 Overexpression Lysate (Adult Normal) [NBL1-16320] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Snx6.

SNX6 Over-expression Lysate Product - GWB-3245FE from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human SNX6 Knockdown Stable Cell Line - CSC-DC014867 from Creative biogene

Category Cell Line
Species Human
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