| Gene Symbol | SNX6 |
|---|---|
| Entrez Gene | 58533 |
| Alt Symbol | MSTP010, TFAF2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | sorting nexin 6 |
| Other Description | TRAF4-associated factor 2|sorting nexin-6|tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2 |
| Swissprots | C0H5W9 Q9UNH7 Q9Y449 |
| Accessions | EAW65913 EAW65914 EAW65915 EAW65916 EAW65917 EAW65918 Q9UNH7 AF109364 AAQ13512 AF121856 AAD27829 AK021456 BAG51034 AK124315 AK292250 BAF84939 AK296213 BAG58939 AK308464 BC001798 AAH01798 BG722853 BI870378 JF432480 ADZ15697 U83194 AAD24202 XM_006720224 XP_006720287 NM_152233 NP_689419 NM_021249 NP_067072 |
| Function | Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). |
| Subcellular Location | Early endosome {ECO:0000269|PubMed:11485546, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774}. Early endosome membrane {ECO:0000269|PubMed:19935774, ECO:0000303|PubMed:11485546}; Peripheral membrane protein {ECO:0000269|PubMed:11485546}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:20354142}. Cytoplasm {ECO:0000269|PubMed:20830743}. Nucleus {ECO:0000269|PubMed:11591366, ECO:0000269|PubMed:20830743}. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes (PubMed:19935774). Only a minor proportion is seen in the nucleus. {ECO:0000269|PubMed:19935774}. |
SNX6 CRISPR/Cas9 KO Plasmid (h) - sc-402113 from Santa Cruz Biotechnology
|
||||||||
SNX6 HDR Plasmid (h) - sc-402113-HDR from Santa Cruz Biotechnology
|
||||||||
SNX6 Double Nickase Plasmid (h) - sc-402113-NIC from Santa Cruz Biotechnology
|
||||||||
SNX6 Double Nickase Plasmid (h2) - sc-402113-NIC-2 from Santa Cruz Biotechnology
|
||||||||
SNX6 CRISPR Activation Plasmid (h) - sc-402113-ACT from Santa Cruz Biotechnology
|
||||||||
SNX6 CRISPR Activation Plasmid (h2) - sc-402113-ACT-2 from Santa Cruz Biotechnology
|
||||||||
SNX6 Lentiviral Activation Particles (h) - sc-402113-LAC from Santa Cruz Biotechnology
|
||||||||
SNX6 Lentiviral Activation Particles (h2) - sc-402113-LAC-2 from Santa Cruz Biotechnology
|
||||||||
SNX6 siRNA (h) - sc-41357 from Santa Cruz Biotechnology
|
||||||||
SNX6 shRNA Plasmid (h) - sc-41357-SH from Santa Cruz Biotechnology
|
||||||||
SNX6 shRNA (h) Lentiviral Particles - sc-41357-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU091191 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN20313 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20313 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR10293 from Sigma-Aldrich
|
||||||||
SNX6 siRNA (Human) - CRJ1752 from Cohesion Biosciences
|
||||||||
SNX6 - MBS828742 from MyBioSource
|
||||||||
shRNA set against Human SNX6 (NM_021249.3) - SHH414856 from Creative biogene
|
||||||||
shRNA set against Human SNX6(NM_021249.3) - SHL023254 from Creative biogene
|
||||||||
shRNA set against Human SNX6(NM_152233.2) - SHL023952 from Creative biogene
|
||||||||
Human SNX6 siRNA - orb272253 from Biorbyt
|
||||||||
SNX6 shRNA Plasmid (Human) - CHJ1752 from Cohesion Biosciences
|
||||||||
SNX6 miRNA 3'UTR clone - MiUTR1H-09725 from Creative biogene
|
||||||||
SNX6 miRNA 3'UTR clone - MiUTR1H-09726 from Creative biogene
|