SNX6

Gene Symbol SNX6
Entrez Gene 58533
Alt Symbol MSTP010, TFAF2
Species Human
Gene Type protein-coding
Description sorting nexin 6
Other Description TRAF4-associated factor 2|sorting nexin-6|tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2
Swissprots C0H5W9 Q9UNH7 Q9Y449
Accessions EAW65913 EAW65914 EAW65915 EAW65916 EAW65917 EAW65918 Q9UNH7 AF109364 AAQ13512 AF121856 AAD27829 AK021456 BAG51034 AK124315 AK292250 BAF84939 AK296213 BAG58939 AK308464 BC001798 AAH01798 BG722853 BI870378 JF432480 ADZ15697 U83194 AAD24202 XM_006720224 XP_006720287 NM_152233 NP_689419 NM_021249 NP_067072
Function Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142).
Subcellular Location Early endosome {ECO:0000269|PubMed:11485546, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774}. Early endosome membrane {ECO:0000269|PubMed:19935774, ECO:0000303|PubMed:11485546}; Peripheral membrane protein {ECO:0000269|PubMed:11485546}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:20354142}. Cytoplasm {ECO:0000269|PubMed:20830743}. Nucleus {ECO:0000269|PubMed:11591366, ECO:0000269|PubMed:20830743}. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes (PubMed:19935774). Only a minor proportion is seen in the nucleus. {ECO:0000269|PubMed:19935774}.

Human Snx6 full length protein - ab163697 from Abcam

Category Protein
Source Wheat germ
Species Human
ab163697 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human Snx6 peptide - ab42881 from Abcam

Category Peptide

SNX6 Antibody Blocking Peptide - LS-E3466 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

SNX6 Antibody Blocking Peptide - LS-E23762 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

SNX6 Antibody Blocking Peptide - LS-E23763 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human Snx6 Protein - H00058533-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Snx6 Peptide - P0441 from Novus Biologicals

Category Peptide
Species Human

SNX6-Antibody-N-term-Blocking-Peptide - BP1464a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Sorting nexin-6 (SNX6) - H00058533-P01-02 from Acris Antibodies

Category Protein
Prices $300.00
Sizes 2 µg
Source in vitro transl.
Species Human

SNX6 fusion protein - ag0168 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

SNX6 fusion protein - Ag20359 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human SNX6, GST-tagged - SNX6-2866H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Sorting nexin-6(SNX6) - CSB-YP890766HU CSB-EP890766HU CSB-BP890766HU CSB-MP890766HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Snx6 Recombinant Protein Antigen - NBP2-13361PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

SNX6-Antibody-Center-Blocking-Peptide - BP1464c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

SNX6 Peptide, Human - M34GP14867H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Sorting nexin-6 (SNX6), Recombinant Protein - MBS1367726 from MyBioSource

Category Protein
Prices $1,180.00, $1,180.00, $1,400.00, $1,400.00, $1,895.00, $1,895.00, $2,360.00, $2,360.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Orangutan

Sorting nexin-6 (SNX6), Recombinant Protein - MBS1459156 from MyBioSource

Category Protein
Prices $1,180.00, $1,180.00, $1,400.00, $1,400.00, $1,895.00, $1,895.00, $2,360.00, $2,360.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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