| Gene Symbol |
LURAP1
|
| Entrez Gene |
541468
|
| Alt Symbol |
C1orf190, LRAP35a, LRP35A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine rich adaptor protein 1
|
| Other Description |
NF-kappa-B activator C1orf190|leucine repeat adapter protein 35A|leucine repeat adaptor protein 35a
|
| Swissprots |
Q96LR2
|
| Accessions |
EAX06931 Q96LR2 AI077554 AK057892 BAB71608 BC034422 AAH34422 BX370151 CR746264 JF432640 ADZ15857 NM_001013615 NP_001013633
|
| Function |
Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway. In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21048106}.
|