Gene Symbol | LURAP1 |
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Entrez Gene | 541468 |
Alt Symbol | C1orf190, LRAP35a, LRP35A |
Species | Human |
Gene Type | protein-coding |
Description | leucine rich adaptor protein 1 |
Other Description | NF-kappa-B activator C1orf190|leucine repeat adapter protein 35A|leucine repeat adaptor protein 35a |
Swissprots | Q96LR2 |
Accessions | EAX06931 Q96LR2 AI077554 AK057892 BAB71608 BC034422 AAH34422 BX370151 CR746264 JF432640 ADZ15857 NM_001013615 NP_001013633 |
Function | Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway. In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21048106}. |
LURAP1 CRISPR/Cas9 KO Plasmid (h) - sc-416081 from Santa Cruz Biotechnology
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LURAP1 HDR Plasmid (h) - sc-416081-HDR from Santa Cruz Biotechnology
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LURAP1 Double Nickase Plasmid (h) - sc-416081-NIC from Santa Cruz Biotechnology
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LURAP1 Double Nickase Plasmid (h2) - sc-416081-NIC-2 from Santa Cruz Biotechnology
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LURAP1 CRISPR Activation Plasmid (h) - sc-416081-ACT from Santa Cruz Biotechnology
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LURAP1 CRISPR Activation Plasmid (h2) - sc-416081-ACT-2 from Santa Cruz Biotechnology
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LURAP1 Lentiviral Activation Particles (h) - sc-416081-LAC from Santa Cruz Biotechnology
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LURAP1 Lentiviral Activation Particles (h2) - sc-416081-LAC-2 from Santa Cruz Biotechnology
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LURAP1 siRNA (h) - sc-78645 from Santa Cruz Biotechnology
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LURAP1 shRNA Plasmid (h) - sc-78645-SH from Santa Cruz Biotechnology
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LURAP1 shRNA (h) Lentiviral Particles - sc-78645-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU111541 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4624 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4624 from Sigma-Aldrich
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LURAP1 siRNA (Human) - CRJ8388 from Cohesion Biosciences
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shRNA set against Human C1orf190 (NM_001013615.2) - SHH250486 from Creative biogene
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Human LURAP1 siRNA - orb278889 from Biorbyt
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LURAP1 shRNA Plasmid (Human) - CHJ8388 from Cohesion Biosciences
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LURAP1 miRNA 3'UTR clone - MiUTR3H-13973 from Creative biogene
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