| Gene Symbol |
PTH1R
|
| Entrez Gene |
5745
|
| Alt Symbol |
PFE, PTHR, PTHR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
parathyroid hormone 1 receptor
|
| Other Description |
PTH/PTHr receptor|PTH/PTHrP type I receptor|PTH1 receptor|parathyroid hormone receptor 1|parathyroid hormone/parathyroid hormone-related peptide receptor|parathyroid hormone/parathyroid hormone-related protein receptor|seven transmembrane helix receptor
|
| Swissprots |
Q03431 Q2M1U3
|
| Accessions |
AAB60657 AAC27643 BAC05721 EAW64793 EAW64794 Q03431 AY449732 AAR18076 BC031578 BC110388 AAI10389 BC112221 AAI12222 BC112247 AAI12248 BQ574694 CA412652 HQ258471 ADR83225 L04308 AAA36525 U17418 AAA56774 X68596 CAA48589 XM_005265344 XP_005265401 XM_011533967 XP_011532269 XM_011533968 XP_011532270 NM_000316 NP_000307 NM_001184744 NP_001171673
|
| Function |
This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:18611381, ECO:0000269|PubMed:20172855}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:20172855}; Multi-pass membrane protein {ECO:0000269|PubMed:20172855}.
|
| Tissue Specificity |
Expressed in most tissues. Most abundant in kidney, bone and liver.
|
| Top Pathways |
Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction
|