Gene Symbol | PTH1R |
---|---|
Entrez Gene | 5745 |
Alt Symbol | PFE, PTHR, PTHR1 |
Species | Human |
Gene Type | protein-coding |
Description | parathyroid hormone 1 receptor |
Other Description | PTH/PTHr receptor|PTH/PTHrP type I receptor|PTH1 receptor|parathyroid hormone receptor 1|parathyroid hormone/parathyroid hormone-related peptide receptor|parathyroid hormone/parathyroid hormone-related protein receptor|seven transmembrane helix receptor |
Swissprots | Q03431 Q2M1U3 |
Accessions | AAB60657 AAC27643 BAC05721 EAW64793 EAW64794 Q03431 AY449732 AAR18076 BC031578 BC110388 AAI10389 BC112221 AAI12222 BC112247 AAI12248 BQ574694 CA412652 HQ258471 ADR83225 L04308 AAA36525 U17418 AAA56774 X68596 CAA48589 XM_005265344 XP_005265401 XM_011533967 XP_011532269 XM_011533968 XP_011532270 NM_000316 NP_000307 NM_001184744 NP_001171673 |
Function | This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:18611381, ECO:0000269|PubMed:20172855}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:20172855}; Multi-pass membrane protein {ECO:0000269|PubMed:20172855}. |
Tissue Specificity | Expressed in most tissues. Most abundant in kidney, bone and liver. |
Top Pathways | Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction |