PTH1R

Gene Symbol PTH1R
Entrez Gene 5745
Alt Symbol PFE, PTHR, PTHR1
Species Human
Gene Type protein-coding
Description parathyroid hormone 1 receptor
Other Description PTH/PTHr receptor|PTH/PTHrP type I receptor|PTH1 receptor|parathyroid hormone receptor 1|parathyroid hormone/parathyroid hormone-related peptide receptor|parathyroid hormone/parathyroid hormone-related protein receptor|seven transmembrane helix receptor
Swissprots Q03431 Q2M1U3
Accessions AAB60657 AAC27643 BAC05721 EAW64793 EAW64794 Q03431 AY449732 AAR18076 BC031578 BC110388 AAI10389 BC112221 AAI12222 BC112247 AAI12248 BQ574694 CA412652 HQ258471 ADR83225 L04308 AAA36525 U17418 AAA56774 X68596 CAA48589 XM_005265344 XP_005265401 XM_011533967 XP_011532269 XM_011533968 XP_011532270 NM_000316 NP_000307 NM_001184744 NP_001171673
Function This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:18611381, ECO:0000269|PubMed:20172855}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:20172855}; Multi-pass membrane protein {ECO:0000269|PubMed:20172855}.
Tissue Specificity Expressed in most tissues. Most abundant in kidney, bone and liver.
Top Pathways Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction

PTH/PTHrP-R (3D1.1) - sc-12722 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PTH/PTHrP-R (3D1.1): sc-12722. Western blot analysis of PTH/PTHrP-R expression in Saos-2 whole cell lysate.

PTH/PTHrP-R (A-14) - sc-25929 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PTH/PTHrP-R (E-16) - sc-25930 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PTH/PTHrP-R (E-16): sc-25930. Western blot analysis of PTH/PTHrP-R expression in PC-12 (A) and KNRK (B) whole cell lysates.

PTH/PTHrP-R (H-125) - sc-20749 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PTH/PTHrP-R (H-125): sc-20749. Immunoperoxidase staining of formalin fixed, paraffin-embedded human nasopharynx tissue showing cytoplasmic and nuclear staining of respiratory epithelial cells.

PTH/PTHrP-R (E-17) - sc-12777 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PTH/PTHrP-R (K-15) - sc-12778 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Parathyroid Hormone Receptor 1 antibody - ab75150 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab75150 staining Parathyroid Hormone Receptor 1 in Lizard regenerated tail (Anolis sagrei) tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with paraformaldehyde and blocked with 1% serum for 45 minutes at 22°C; antigen retrieval was by heat mediation in sodium citrate buffer, pH 6.0. Samples were incubated with primary antibody (1/200 in 1% horse serum) for 16 hours at 4°C. A Biotin-conjugated horse anti-rabbit IgG polyclonal (1/50) was used as the secondary antibody.Image is of a regenerated lizard tail cartilage tube, at a proximal region that has begun to ossify. Positive staining was observed in structures resembling embryonic bone collar and early hypertrophic chondrocytes.See Abreview

Anti-Parathyroid Hormone Receptor 1 antibody - ab73922 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ab73922, at 1/50 dilution, staining Parathyroid Hormone Receptor 1 in Human Parathyroid by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

Anti-Parathyroid Hormone Receptor 1 antibody - ab13078 from Abcam

Prices $359.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry with ab13078 on a Kidney (collecting ducts of the cortex) section.

Anti-Parathyroid Hormone Receptor 1 antibody [3D1.1] - ab3271 from Abcam

Prices $382.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 3D1.1
Immunohistochemical analysis of rabbit bone treated with Parathyroid Hormone, staining Parathyroid Hormone Receptor 1 with ab3271. Antigen retrieval was performed by heat mediation in a citrate buffer and tissue was then blocked with protein block solution for 20 minutes. Sections were incubated with primary antibody (1/50) overnight in a humid chamber before incubating with a biotinylated secondary antibody. Staining was detected using DAB.

Anti-Parathyroid Hormone Receptor 1 antibody [3D1.1] - ab80704 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3D1.1
Formalin-fixed, paraffin-embedded human breast carcinoma stained with ab80704 at 4µg/ml using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.

Anti-Parathyroid Hormone Receptor 1 antibody [4D2] - ab104832 from Abcam

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4D2
Overlay histogram showing HepG2 cells stained with ab104832 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab104832, 1/50 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H+L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HepG2 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Parathyroid Hormone Receptor 1 antibody [EPR15892] - ab189924 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15892
Anti-Parathyroid Hormone Receptor 1 antibody [EPR15892] (ab189924) at 1/10000 dilution + HeLa cell lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-Parathyroid Hormone Receptor 1 antibody [OK1] - ab24752 from Abcam

Prices $359.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone OK1

Anti-Parathyroid Hormone Receptor 1 antibody, prediluted - ab73926 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab73926 staining Parathyroid Hormone Receptor 1 in Human Parathyroid by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

Anti-PTHR / PTHR1 Antibody (aa146-169) - LS-C25981 from LifeSpan Bioscience

Prices $455.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal

Anti-PTHR / PTHR1 Antibody (aa23-189) - LS-C124346 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-PTHR / PTHR1 Antibody (clone SPM209) - LS-C189150 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone SPM209

Anti-PTHR / PTHR1 Antibody (clone 3D11, Azide-free) - LS-C87651 from LifeSpan Bioscience

Prices $620.00, $1,015.00
Sizes 100 µg, 200 µg
Host Mouse
Clonality Monoclonal
Clone 3D11
Formalin-fixed, paraffin-embedded human breast carcinoma stained with peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.

Anti-PTHR / PTHR1 Antibody (clone 3D1.1) IHC-plus™ - LS-B7767 from LifeSpan Bioscience

Prices $395.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone 3D1.1
Anti-PTHR / PTHR1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7767 dilution 20 ug/ml.

Anti-PTHR / PTHR1 Antibody - LS-C192884 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts of Jurkat cell lines, using PTH1R antibody.

Anti-PTHR / PTHR1 Antibody (N-Terminus) - LS-C210495 from LifeSpan Bioscience

Prices $360.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of Human Parathyroid Gland stained with anti-Parathyroid Hormone Receptor 1 antibody

Anti-PTHR / PTHR1 Antibody (N-Terminus) - LS-C201397 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human ACHN. PTH1R antibody dilution 1.0 ug/ml.

Anti-PTHR / PTHR1 Antibody - LS-C331666 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human kidney cancer using PTH1R antibody at dilution of 1:200 (x400 lens)

Anti-PTHR / PTHR1 Antibody (aa388-406) - LS-C313515 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
PTHR / PTHR1 antibody. IHC(P): Human Thyroid Cancer Tissue.
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