IKBKE

Gene Symbol	IKBKE
Entrez Gene	9641
Alt Symbol	IKK-E, IKK-i, IKKE, IKKI
Species	Human
Gene Type	protein-coding
Description	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Other Description	I-kappa-B kinase epsilon|IKK-epsilon|IKK-related kinase epsilon|inducible I kappa-B kinase|inducible IkappaB kinase|inhibitor of nuclear factor kappa-B kinase subunit epsilon
Swissprots	Q14164 Q5JTS6 D3DT78 Q3KR43 Q3B754
Accessions	ABG25921 CAC09147 CAI15250 CAT02203 EAW93547 EAW93548 EAW93549 Q14164 AB016590 BAA85155 AF241789 AAF45307 AK093798 AK310737 AL706097 AY660028 BC105923 AAI05924 BC105924 AAI05925 BC107591 BC107812 AAI07813 CB243308 D63485 BAA09772 DA990116 DA999897 DB152295 XM_005273356 XP_005273413 XR_922002 NM_001193321 NP_001180250 NM_001193322 NP_001180251 NM_014002 NP_054721
Function	Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG- I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1,
Subcellular Location	Cytoplasm. Nucleus. Nucleus, PML body. Note=Targeting to PML nuclear bodies upon DNA damage is TOPORS- dependent.
Tissue Specificity	Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.
Top Pathways	Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Hepatitis C, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Inhibitor of nuclear factor kappa-B kinase subunit epsilon, IKBKE, Human, ELISA Kit - E14976h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 78-5000 pg/mL

Mouse IKBKE / IKKI / IKKE ELISA Kit (Sandwich ELISA) - LS-F17574 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 78-5000 pg/ml

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon, ELISA Kit - MBS9330267 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human Inhibitor of nuclear factor kappa-B kinase subunit epsilon ELISA Kit - abx250991 from Abbexa Category ELISA Kit Range 78 pg/ml - 5000 pg/ml

Human IKBKE / IKKI / IKKE ELISA Kit (Sandwich ELISA) - LS-F13253 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 78-5000 pg/ml

Human Inhibitor of nuclear factor kappa-B kinase subunit epsilon ELISA Kit - EKE54654 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 49 pg/ml Range 78-5000 pg/mL

IKBKE - EKH3384 from Nordic BioSite Sensitivity 46.9pg/ml Range 78-5000pg/ml

IKBKE ELISA Kit (Human) (OKEH02409) - OKEH02409 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 49 pg/mL Range 78 - 5,000 pg/mL

Human IKBKE ELISA Kit - E019817 from Biobool Category ELISA Kit

Human Inhibitor of nuclear factor kappa-B kinase subunit epsilon ELISA Kit - EK3534 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Sensitivity less than 49 pg/ml Range 78-5000 pg/mL

Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon (IKBKE), ELISA Kit - MBS9344263 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon (IKBKE), ELISA Kit - MBS9358399 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon (IKBKE), ELISA Kit - MBS9351098 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon (IKBKE), ELISA Kit - MBS9359494 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon (IKBKE), ELISA Kit - MBS9350689 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon (IKBKE), ELISA Kit - MBS9358452 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon (IKBKE), ELISA Kit - MBS9343570 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon (IKBKE), ELISA Kit - MBS9343745 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon (IKBKE), ELISA Kit - MBS9349007 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon (IKBKE), ELISA Kit - MBS9364536 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon (IKBKE), ELISA Kit - MBS9360585 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon (IKBKE), ELISA Kit - MBS9349586 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon (IKBKE), ELISA Kit - MBS9367300 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon (IKBKE), ELISA Kit - MBS9351956 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inhibitor of nuclear factor kappa-B kinase subunit epsilon, ELISA Kit - MBS764692 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.9pg/ml Range 78-5000pg/ml

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