| Gene Symbol |
IKBKE
|
| Entrez Gene |
9641
|
| Alt Symbol |
IKK-E, IKK-i, IKKE, IKKI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
|
| Other Description |
I-kappa-B kinase epsilon|IKK-epsilon|IKK-related kinase epsilon|inducible I kappa-B kinase|inducible IkappaB kinase|inhibitor of nuclear factor kappa-B kinase subunit epsilon
|
| Swissprots |
Q14164 Q5JTS6 D3DT78 Q3KR43 Q3B754
|
| Accessions |
ABG25921 CAC09147 CAI15250 CAT02203 EAW93547 EAW93548 EAW93549 Q14164 AB016590 BAA85155 AF241789 AAF45307 AK093798 AK310737 AL706097 AY660028 BC105923 AAI05924 BC105924 AAI05925 BC107591 BC107812 AAI07813 CB243308 D63485 BAA09772 DA990116 DA999897 DB152295 XM_005273356 XP_005273413 XR_922002 NM_001193321 NP_001180250 NM_001193322 NP_001180251 NM_014002 NP_054721
|
| Function |
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG- I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1,
|
| Subcellular Location |
Cytoplasm. Nucleus. Nucleus, PML body. Note=Targeting to PML nuclear bodies upon DNA damage is TOPORS- dependent.
|
| Tissue Specificity |
Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.
|
| Top Pathways |
Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Hepatitis C, Measles
|
