IKBKE

Gene Symbol	IKBKE
Entrez Gene	9641
Alt Symbol	IKK-E, IKK-i, IKKE, IKKI
Species	Human
Gene Type	protein-coding
Description	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Other Description	I-kappa-B kinase epsilon|IKK-epsilon|IKK-related kinase epsilon|inducible I kappa-B kinase|inducible IkappaB kinase|inhibitor of nuclear factor kappa-B kinase subunit epsilon
Swissprots	Q14164 Q5JTS6 D3DT78 Q3KR43 Q3B754
Accessions	ABG25921 CAC09147 CAI15250 CAT02203 EAW93547 EAW93548 EAW93549 Q14164 AB016590 BAA85155 AF241789 AAF45307 AK093798 AK310737 AL706097 AY660028 BC105923 AAI05924 BC105924 AAI05925 BC107591 BC107812 AAI07813 CB243308 D63485 BAA09772 DA990116 DA999897 DB152295 XM_005273356 XP_005273413 XR_922002 NM_001193321 NP_001180250 NM_001193322 NP_001180251 NM_014002 NP_054721
Function	Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG- I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1,
Subcellular Location	Cytoplasm. Nucleus. Nucleus, PML body. Note=Targeting to PML nuclear bodies upon DNA damage is TOPORS- dependent.
Tissue Specificity	Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.
Top Pathways	Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Hepatitis C, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human IKKi/IKKe full length protein - ab201367 from Abcam Category Protein Prices $337.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human IKKi/IKKe protein fragment - ab153006 from Abcam Category Protein Source Wheat germ Species Human

IKKi/IKKe peptide - ab7897 from Abcam Category Peptide

IKBKE / IKKI / IKKE Antibody Blocking Peptide - LS-E3147 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IKBKE / IKKI / IKKE Antibody Blocking Peptide - LS-E23055 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IKBKE / IKKI / IKKE Antibody Blocking Peptide - LS-E29946 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

IKBKE / IKKI / IKKE Antibody Blocking Peptide - LS-E9522 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IKK epsilon/IKBKE Partial Recombinant Protein - H00009641-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

Recombinant Human IKK epsilon/IKBKE Protein - P4704 from Novus Biologicals Category Protein Prices $1,599.00 Sizes 100 µg Source Insect Species Human

IKK epsilon/IKBKE Peptide - NBP1-76800PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

IKK epsilon/IKBKE Peptide - P3153 from Novus Biologicals Category Peptide Species Human

IKK-epsilon-IKKE-Antibody-C-term-Blocking-peptide - BP8138b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IKBKE peptide - GTX27897 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

IKBKE / IKKE - H00009641-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

IKBKE / IKKE - H00009641-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

IKBKE / IKKE - P4704 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

IKBKE / IKKE - P5721 from Acris Antibodies Category Protein Prices $1,180.00 Sizes 5 µg Species Human

IKK epsilon Peptide - 2329P from ProSci Category Peptide Species Human

IKBKE fusion protein - ag16037 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

IKBKE fusion protein - ag17234 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant IKKε protein - 31177 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source Baculovirus Species Human

Recombinant Human IKBKE, GST-tagged - IKBKE-14133H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human IKBKE, GST-tagged - IKBKE-125H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant Human IKBKE, GST-His - IKBKE-2662H from Creative Biomart Category Protein Source Sf9 insect cells.

IKKε Protein, active, 10 µg - 14-926 from EMD Millipore Category Protein Prices $401.00 Sizes 10 µg also available in 250μg size as catalog # 14-926m and in bulk as catalog # 14-926-k. Source N-terminal FLAG and GST-tagged, recombinant, human IKK full length, expressed by baculovirus in Sf21 insect cells.

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