IKBKE

Gene Symbol	IKBKE
Entrez Gene	9641
Alt Symbol	IKK-E, IKK-i, IKKE, IKKI
Species	Human
Gene Type	protein-coding
Description	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Other Description	I-kappa-B kinase epsilon|IKK-epsilon|IKK-related kinase epsilon|inducible I kappa-B kinase|inducible IkappaB kinase|inhibitor of nuclear factor kappa-B kinase subunit epsilon
Swissprots	Q14164 Q5JTS6 D3DT78 Q3KR43 Q3B754
Accessions	ABG25921 CAC09147 CAI15250 CAT02203 EAW93547 EAW93548 EAW93549 Q14164 AB016590 BAA85155 AF241789 AAF45307 AK093798 AK310737 AL706097 AY660028 BC105923 AAI05924 BC105924 AAI05925 BC107591 BC107812 AAI07813 CB243308 D63485 BAA09772 DA990116 DA999897 DB152295 XM_005273356 XP_005273413 XR_922002 NM_001193321 NP_001180250 NM_001193322 NP_001180251 NM_014002 NP_054721
Function	Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG- I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1,
Subcellular Location	Cytoplasm. Nucleus. Nucleus, PML body. Note=Targeting to PML nuclear bodies upon DNA damage is TOPORS- dependent.
Tissue Specificity	Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.
Top Pathways	Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Hepatitis C, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IKK-i CRISPR/Cas9 KO Plasmid (h) - sc-401786 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IKK-i HDR Plasmid (h) - sc-401786-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IKK-i Double Nickase Plasmid (h) - sc-401786-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IKK-i Double Nickase Plasmid (h2) - sc-401786-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IKK-i CRISPR Activation Plasmid (h) - sc-401786-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IKK-i CRISPR Activation Plasmid (h2) - sc-401786-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IKK-i Lentiviral Activation Particles (h) - sc-401786-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IKK-i Lentiviral Activation Particles (h2) - sc-401786-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IKK-i siRNA (h) - sc-39056 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IKK-i shRNA Plasmid (h) - sc-39056-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IKK-i shRNA (h) Lentiviral Particles - sc-39056-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IKK epsilon/IKBKE RNAi - H00009641-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU143291 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK0955 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0956 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0954 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN10554 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10554 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06240 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr06240

IKBKE siRNA (Human) - CRH6419 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IKBKE - MBS8234845 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human IKBKE (NM_014002.3) - SHH318013 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human IKBKE(NM_001193321.1) - SHL170002 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human IKBKE(NM_001193322.1) - SHL170152 from Creative biogene Category siRNA Species Reactivities Human

Human IKBKE siRNA - orb266921 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

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