| Gene Symbol |
APLP1
|
| Entrez Gene |
333
|
| Alt Symbol |
APLP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
amyloid beta (A4) precursor-like protein 1
|
| Other Description |
APLP-1|amyloid precursor-like protein 1|amyloid-like protein 1
|
| Swissprots |
Q96A92 P51693 O00113
|
| Accessions |
AAB50173 P51693 AK092376 AK126907 AK297339 BAH12554 AK297640 BAH12638 AK312292 BAG35219 BC012889 AAH12889 BC013850 BC032983 BQ219233 DQ891341 ABM82267 DQ894523 ABM85449 EF036503 ABO65089 U48437 AAB96331 NM_001024807 NP_001019978 NM_005166 NP_005157
|
| Function |
May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD). {ECO:0000269|PubMed:7494461}.
|
![Western Blot: APLP1 Overexpression Lysate (Adult Normal) [NBL1-07607] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for APLP1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/13141_APLP1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-07607-img0002.jpg)