Gene Symbol | APLP1 |
---|---|
Entrez Gene | 333 |
Alt Symbol | APLP |
Species | Human |
Gene Type | protein-coding |
Description | amyloid beta (A4) precursor-like protein 1 |
Other Description | APLP-1|amyloid precursor-like protein 1|amyloid-like protein 1 |
Swissprots | Q96A92 P51693 O00113 |
Accessions | AAB50173 P51693 AK092376 AK126907 AK297339 BAH12554 AK297640 BAH12638 AK312292 BAG35219 BC012889 AAH12889 BC013850 BC032983 BQ219233 DQ891341 ABM82267 DQ894523 ABM85449 EF036503 ABO65089 U48437 AAB96331 NM_001024807 NP_001019978 NM_005166 NP_005157 |
Function | May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. {ECO:0000250}. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD). {ECO:0000269|PubMed:7494461}. |