ALOX12

Gene Symbol	ALOX12
Entrez Gene	239
Alt Symbol	12-LOX, 12S-LOX, LOG12
Species	Human
Gene Type	protein-coding
Description	arachidonate 12-lipoxygenase
Other Description	12(S)-lipoxygenase|12S-lipoxygenase|arachidonate 12-lipoxygenase, 12S-type|lipoxin synthase 12-LO|platelet 12-LOX|platelet-type 12-lipoxygenase|platelet-type lipoxygenase 12
Swissprots	P18054 Q9UQM4 Q6ISF8 O95569
Accessions	AAA51587 AAS00094 BAA02162 EAW90281 P18054 AF143883 AAD32700 BC069557 AAH69557 M35418 AAA60056 M58704 AAA59523 M62982 AAA51533 S68587 AAD14020 S68588 AAD14021 XM_011523780 XP_011522082 NM_000697 NP_000688
Function	Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. {ECO:0000269|PubMed:16638750, ECO:0000269|PubMed:22237009, ECO:0000269|PubMed:23578768, ECO:0000269|PubMed:82
Subcellular Location	Cytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF.
Tissue Specificity	Expressed in vascular smooth muscle cells. {ECO:0000269|PubMed:23578768}.
Top Pathways	Inflammatory mediator regulation of TRP channels, Arachidonic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ALOX12 / 12 Lipoxygenase ELISA Kit (Sandwich ELISA) - LS-F9553 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.116 ng/ml Range 0.313-20 ng/ml

Human ALOX12 ELISA Kit - abx150617 from Abbexa Category ELISA Kit Sensitivity 0.116 ng/ml Range 0.313 ng/ml - 20 ng/ml

Arachidonate 12-Lipoxygenase, 12-LO, Human, ELISA Kit - E-EL-H2445 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Arachidonate 12-lipoxygenase, 12S-type (ALOX12/LOG12), Human, ELISA Kit - CSB-E16996h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Arachidonate 12-lipoxygenase, 12S-type (ALOX12/LOG12), Human, ELISA Kit - E01A1398 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Arachidonate 12-lipoxygenase, 12S-type, ALOX12, Human, ELISA Kit - E1965h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t

Arachidonate-12-Lipoxygenase (ALOX12), Human, ELISA Kit - SEB965Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.116ng/mL Range 0.312-20ng/mL

Arachidonate 12-Lipoxygenase, 12-LO, Mouse, ELISA Kit - E-EL-M1279 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Arachidonate 12-Lipoxygenase, 12-LO, Rat, ELISA Kit - E-EL-R1000 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

ALOX12 (Human) Matched Antibody Pair - H00000239-AP21 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Arachidonate 12 lipoxygenase, 12S type (ALOX12/LOG12), ELISA Kit - MBS7211564 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

arachidonate 12-lipoxygenase, ELISA Kit - MBS706230 from MyBioSource Category ELISA Kit Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12S-type (ALOX12/LOG12), ELISA Kit - MBS7229228 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12S-type (ALOX12/LOG12), ELISA Kit - MBS7204408 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12S-type (ALOX12/LOG12), ELISA Kit - MBS7237203 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12S-type (ALOX12/LOG12), ELISA Kit - MBS7227237 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12S-type (ALOX12/LOG12), ELISA Kit - MBS7236711 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12S-type (ALOX12/LOG12), ELISA Kit - MBS7243128 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12S-type (ALOX12/LOG12), ELISA Kit - MBS7206837 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12S-type (ALOX12/LOG12), ELISA Kit - MBS7208655 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12S-type (ALOX12/LOG12), ELISA Kit - MBS7210733 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate 12-lipoxygenase, 12S-type (ALOX12/LOG12), ELISA Kit - MBS7241966 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Arachidonate-12-Lipoxygenase (ALOX12), ELISA Kit - MBS2000243 from MyBioSource Category ELISA Kit Prices $355.00, $540.00, $730.00, $2,985.00, $5,410.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.116ng/mL. Range 0.313-20ng/mL

ELISA Kit for Arachidonate-12-Lipoxygenase (ALOX12) - SEB965Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.116ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human Arachidonate 12-lipoxygenase, 12S-type (ALOX12/LOG12) ELISA kit - CSB-E16996h from Cusabio Category ELISA Kit Sensitivity 0.31 ng/ml Range 1.25 ng/ml-80 ng/ml

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