ALOX12
| Gene Symbol | ALOX12 |
|---|---|
| Entrez Gene | 239 |
| Alt Symbol | 12-LOX, 12S-LOX, LOG12 |
| Species | Human |
| Gene Type | protein-coding |
| Description | arachidonate 12-lipoxygenase |
| Other Description | 12(S)-lipoxygenase|12S-lipoxygenase|arachidonate 12-lipoxygenase, 12S-type|lipoxin synthase 12-LO|platelet 12-LOX|platelet-type 12-lipoxygenase|platelet-type lipoxygenase 12 |
| Swissprots | P18054 Q9UQM4 Q6ISF8 O95569 |
| Accessions | AAA51587 AAS00094 BAA02162 EAW90281 P18054 AF143883 AAD32700 BC069557 AAH69557 M35418 AAA60056 M58704 AAA59523 M62982 AAA51533 S68587 AAD14020 S68588 AAD14021 XM_011523780 XP_011522082 NM_000697 NP_000688 |
| Function | Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. {ECO:0000269|PubMed:16638750, ECO:0000269|PubMed:22237009, ECO:0000269|PubMed:23578768, ECO:0000269|PubMed:82 |
| Subcellular Location | Cytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF. |
| Tissue Specificity | Expressed in vascular smooth muscle cells. {ECO:0000269|PubMed:23578768}. |
| Top Pathways | Inflammatory mediator regulation of TRP channels, Arachidonic acid metabolism |
12-LO CRISPR/Cas9 KO Plasmid (h) - sc-403010 from Santa Cruz Biotechnology
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12-LO HDR Plasmid (h) - sc-403010-HDR from Santa Cruz Biotechnology
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12-LO Double Nickase Plasmid (h) - sc-403010-NIC from Santa Cruz Biotechnology
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12-LO Double Nickase Plasmid (h2) - sc-403010-NIC-2 from Santa Cruz Biotechnology
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12-LO CRISPR Activation Plasmid (h) - sc-403010-ACT from Santa Cruz Biotechnology
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12-LO CRISPR Activation Plasmid (h2) - sc-403010-ACT-2 from Santa Cruz Biotechnology
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12-LO Lentiviral Activation Particles (h) - sc-403010-LAC from Santa Cruz Biotechnology
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12-LO Lentiviral Activation Particles (h2) - sc-403010-LAC-2 from Santa Cruz Biotechnology
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12-LO siRNA (h) - sc-45984 from Santa Cruz Biotechnology
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12-LO shRNA Plasmid (h) - sc-45984-SH from Santa Cruz Biotechnology
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12-LO shRNA (h) Lentiviral Particles - sc-45984-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU007981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3077 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3077 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02962 from Sigma-Aldrich
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ALOX12 siRNA (Human) - CRH0166 from Cohesion Biosciences
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12-Lipoxygenase RNAi - H00000239-R01 from Novus Biologicals
![RNAi sequence position: 12 Lipoxygenase RNAi [H00000239-R01] - Position of the Chimera RNAi.](http://www.bioprodhub.com/system/product_images/rna_products/5/sub_1/18585_12%2520Lipoxygenase%2520RNAi-RNAi%2520sequence%2520position-H00000239-R01-img0001.jpg)
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ALOX12 - MBS8207008 from MyBioSource
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shRNA set against Human ALOX12(NM_000697.2) - SHG031849 from Creative biogene
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Human ALOX12 siRNA - orb260668 from Biorbyt
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ALOX12 shRNA Plasmid (Human) - CHH0166 from Cohesion Biosciences
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ALOX12 miRNA 3'UTR clone - MiUTR1H-00311 from Creative biogene
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