| Gene Symbol |
ALOX12
|
| Entrez Gene |
239
|
| Alt Symbol |
12-LOX, 12S-LOX, LOG12
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
arachidonate 12-lipoxygenase
|
| Other Description |
12(S)-lipoxygenase|12S-lipoxygenase|arachidonate 12-lipoxygenase, 12S-type|lipoxin synthase 12-LO|platelet 12-LOX|platelet-type 12-lipoxygenase|platelet-type lipoxygenase 12
|
| Swissprots |
P18054 Q9UQM4 Q6ISF8 O95569
|
| Accessions |
AAA51587 AAS00094 BAA02162 EAW90281 P18054 AF143883 AAD32700 BC069557 AAH69557 M35418 AAA60056 M58704 AAA59523 M62982 AAA51533 S68587 AAD14020 S68588 AAD14021 XM_011523780 XP_011522082 NM_000697 NP_000688
|
| Function |
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. {ECO:0000269|PubMed:16638750, ECO:0000269|PubMed:22237009, ECO:0000269|PubMed:23578768, ECO:0000269|PubMed:82
|
| Subcellular Location |
Cytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF.
|
| Tissue Specificity |
Expressed in vascular smooth muscle cells. {ECO:0000269|PubMed:23578768}.
|
| Top Pathways |
Inflammatory mediator regulation of TRP channels, Arachidonic acid metabolism
|
![Western Blot: 12 Lipoxygenase Lysate [H00000239-T01] - Lane 1: ALOX12 transfected lysate (75.7 KDa) Lane 2: Non-transfected lysate.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/383_12%2520Lipoxygenase%2520Lysate-Western%2520Blot-H00000239-T01-img0002.jpg)
![Western Blot: 12 Lipoxygenase Overexpression Lysate (Adult Normal) [NBP2-10693] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for 12 Lipoxygenase.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/25679_12%2520Lipoxygenase%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-10693-img0001.jpg)