ALOX12

Gene Symbol	ALOX12
Entrez Gene	239
Alt Symbol	12-LOX, 12S-LOX, LOG12
Species	Human
Gene Type	protein-coding
Description	arachidonate 12-lipoxygenase
Other Description	12(S)-lipoxygenase|12S-lipoxygenase|arachidonate 12-lipoxygenase, 12S-type|lipoxin synthase 12-LO|platelet 12-LOX|platelet-type 12-lipoxygenase|platelet-type lipoxygenase 12
Swissprots	P18054 Q9UQM4 Q6ISF8 O95569
Accessions	AAA51587 AAS00094 BAA02162 EAW90281 P18054 AF143883 AAD32700 BC069557 AAH69557 M35418 AAA60056 M58704 AAA59523 M62982 AAA51533 S68587 AAD14020 S68588 AAD14021 XM_011523780 XP_011522082 NM_000697 NP_000688
Function	Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. {ECO:0000269|PubMed:16638750, ECO:0000269|PubMed:22237009, ECO:0000269|PubMed:23578768, ECO:0000269|PubMed:82
Subcellular Location	Cytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF.
Tissue Specificity	Expressed in vascular smooth muscle cells. {ECO:0000269|PubMed:23578768}.
Top Pathways	Inflammatory mediator regulation of TRP channels, Arachidonic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human 12 Lipoxygenase full length protein - ab112250 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human 12 Lipoxygenase protein fragment - ab152177 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

ALOX12 / 12 Lipoxygenase Antibody Blocking Peptide - LS-E9829 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human 12-Lipoxygenase Protein - H00000239-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

12-Lipoxygenase Partial Recombinant Protein - H00000239-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ALOX12-Antibody-C-term-Blocking-Peptide - BP8877b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ALOX12-Antibody-N-term-Blocking-Peptide - BP8877a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ALOX12 Blocking Peptide - 33R-6077 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ALOX12 / LOG12 - H00000239-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ALOX12 / LOG12 - H00000239-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ALOX12 / LOG12 - H00000239-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ALOX12 / LOG12 - H00000239-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human ALOX12 - ALOX12-269H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant human ALOX12, His-tagged - ALOX12-01H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Arachidonate-12-Lipoxygenase (ALOX12) - RPB965Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Arachidonate-12-Lipoxygenase (ALOX12) - RPB965Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Arachidonate 12-lipoxygenase, 12S-type(ALOX12) - CSB-YP001617HU CSB-EP001617HU CSB-BP001617HU CSB-MP001617HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ALOX12 / LOG12 - TP310211 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Arachidonate 12-lipoxygenase, 12S-type (ALOX12) , Recombinant Protein - MBS964965 from MyBioSource Category Protein Prices $2,490.00, $2,490.00, $2,915.00, $2,915.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Arachidonate-12-Lipoxygenase, Recombinant Protein - MBS2029841 from MyBioSource Category Protein Prices $260.00, $465.00, $680.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

12-Lipoxygenase Recombinant Protein Antigen - NBP1-90338PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ALOX12 Peptide, Human - M34GP00521H from Creative Peptides Category Peptide Source Synthetic. Species Human

ALOX12 fusion protein - Ag26648 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

ALOX12 Recombinant Protein (OPCD01256) - OPCD01256 from Aviva Systems Biology Category Protein Source E.coli Species Human

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