CARD16

Gene Symbol CARD16
Entrez Gene 114769
Alt Symbol COP, COP1, PSEUDO-ICE
Species Human
Gene Type protein-coding
Description caspase recruitment domain family, member 16
Other Description CARD only domain-containing protein 1|CARD only protein|CARD-only protein 1|caspase recruitment domain-containing protein 16|caspase recruitment domain-only protein 1|caspase-1 dominant-negative inhibitor pseudo-ICE|caspase-1 inhibitor COP|pseudo interleukin-1 beta converting enzyme|pseudo interleukin-1beta converting enzyme|pseudo-IL1B-converting enzyme
Swissprots Q5EG05 Q96RJ9
Accessions EAW67062 Q5EG05 AF367017 AAK71682 AK125640 AK311902 BAG34843 AY885669 AAW78563 BC033638 BC070196 BC104635 BC117478 AAI17479 BC117480 AAI17481 BC141473 AAI41474 BC148760 AAI48761 XM_011542583 XP_011540885 NM_001017534 NP_001017534 NM_052889 NP_443121
Function Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. {ECO:0000269|PubMed:11432859, ECO:0000269|PubMed:11536016, ECO:0000269|PubMed:16920334}.
Tissue Specificity Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus. {ECO:0000269|PubMed:11432859, ECO:0000269|PubMed:11536016}.

Anti-COP antibody - ab168243 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-COP antibody (ab168243) at 1 µg/mlLane 1 : COP transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-COP antibody - ab168257 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-COP antibody (ab168257) at 1 µg/mlLane 1 : COP transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-COP antibody - ab188069 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human nasopharynx tissue labeling COP with ab188069 at 1/20 dilution.

Anti-COP antibody - ab57714 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57714 COP antibody at 1ug/ml.

Anti-COP antibody - ab2225 from Abcam

Prices $242.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CARD16 / COP Antibody (aa85-97) - LS-C54670 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CARD16 / COP Antibody (aa37-65, APC) - LS-C234113 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CARD16 / COP Antibody (aa37-65, AP) - LS-C234116 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CARD16 / COP Antibody (aa37-65, Biotin) - LS-C234114 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CARD16 / COP Antibody (aa37-65, FITC) - LS-C234117 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CARD16 / COP Antibody (aa37-65, PE) - LS-C234119 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CARD16 / COP Antibody (aa37-65, Azide-free, HRP) - LS-C249730 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CARD16 / COP Antibody (aa1-98) - LS-C307053 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CARD16 / COP Antibody - LS-C307052 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-CARD16 / COP Antibody (aa44-73) - LS-C320519 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CARD16 / COP Antibody - LS-C309964 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CARD16 / COP Antibody (aa37-65) - LS-C166940 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
COP1 Antibody western blot of CEM,A549 cell line lysates (35 ug/lane). The COP1 antibody detected the COP1 protein (arrow).

COP1 Antibody - NBP1-85516 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: COP1 Antibody [NBP1-85516] Staining of human cell line U-251MG shows positivity in nucleus but not nucleoli & focal adhesions.

COP Antibody - H00114769-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

COP Antibody - H00114769-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: COP Antibody [H00114769-B01] - analysis of COP1 expression in transfected 293T cell line by COP1 MaxPab polyclonal antibody (B01). Lane 1: COP1 transfected lysate (10.70 KDa). Lane 2: Non-transfected lysate.

COP Antibody - NBP2-30778 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: COP Antibody [NBP2-30778] - Staining of human nasopharynx shows strong cytoplasmic positivity in respiratory epithelial cells.

COP Antibody (3E10) - H00114769-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3E10
Sandwich ELISA: COP Antibody (3E10) [H00114769-M01] - Detection limit for recombinant GST tagged COP1 is approximately 0.03ng/ml as a capture antibody.

COP Antibody - H00114769-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: COP Antibody [H00114769-D01P] - Analysis of CARD16 expression in human spleen.

COP Antibody - H00114769-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

COP Antibody - NB100-856 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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