CARD16

Gene Symbol	CARD16
Entrez Gene	114769
Alt Symbol	COP, COP1, PSEUDO-ICE
Species	Human
Gene Type	protein-coding
Description	caspase recruitment domain family, member 16
Other Description	CARD only domain-containing protein 1|CARD only protein|CARD-only protein 1|caspase recruitment domain-containing protein 16|caspase recruitment domain-only protein 1|caspase-1 dominant-negative inhibitor pseudo-ICE|caspase-1 inhibitor COP|pseudo interleukin-1 beta converting enzyme|pseudo interleukin-1beta converting enzyme|pseudo-IL1B-converting enzyme
Swissprots	Q5EG05 Q96RJ9
Accessions	EAW67062 Q5EG05 AF367017 AAK71682 AK125640 AK311902 BAG34843 AY885669 AAW78563 BC033638 BC070196 BC104635 BC117478 AAI17479 BC117480 AAI17481 BC141473 AAI41474 BC148760 AAI48761 XM_011542583 XP_011540885 NM_001017534 NP_001017534 NM_052889 NP_443121
Function	Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. {ECO:0000269|PubMed:11432859, ECO:0000269|PubMed:11536016, ECO:0000269|PubMed:16920334}.
Tissue Specificity	Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus. {ECO:0000269|PubMed:11432859, ECO:0000269|PubMed:11536016}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human COP full length protein - ab131837 from Abcam Category Protein Source Wheat germ Species Human

Human COP peptide - ab22869 from Abcam Category Peptide Species Human

Human COP protein fragment - ab165027 from Abcam Category Protein Source Wheat germ Species Human

CARD16 / COP Antibody Blocking Peptide - LS-E924 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CARD16 / COP Antibody Blocking Peptide - LS-E25276 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human COP Protein - H00114769-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human COP Protein - H00114769-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

COP1-Antibody-N-term-Blocking-peptide - BP11328a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

COP1/PSEUDO-ICE (Isofom 2) blocking peptide - GTX89959-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

COP Peptide - AC21-0104-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CARD16 / COP1 - H00114769-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CARD16 / COP1 - H00114769-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CARD16 / COP1 - H00114769-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CARD16 / COP1 - H00114769-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

COP1 Peptide - 45-417P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

Recombinant Protein cop(cop) - CSB-YP815792FLL CSB-EP815792FLL CSB-BP815792FLL CSB-MP815792FLL from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Staphylococcus

Recombinant Protein cop(cop) - CSB-YP687480FKZ CSB-EP687480FKZ CSB-BP687480FKZ CSB-MP687480FKZ from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Staphylococcus

Recombinant Human Caspase recruitment domain-containing protein 16(CARD16) - CSB-YP682727HU CSB-EP682727HU CSB-BP682727HU CSB-MP682727HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Protein cop(cop) - CSB-YP361169FKZ CSB-EP361169FKZ CSB-BP361169FKZ CSB-MP361169FKZ from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Staphylococcus

CARD16 / COP1 (transcript variant 2) - TP311537 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CARD16 / COP1 (full length, N-term HIS tag, transcript variant 1) - TP760353 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

Caspase recruitment domain-containing protein 16 (CARD16), Recombinant Protein - MBS1419691 from MyBioSource Category Protein Prices $945.00, $945.00, $1,170.00, $1,170.00, $1,410.00, $1,410.00, $1,875.00, $1,875.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

COP1/PSEUDO-ICE, Peptide - MBS425386 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

COP Recombinant Protein Antigen - NBP2-30778PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CARD16 Peptide, Human - M34GP02368H from Creative Peptides Category Peptide Source Synthetic. Species Human

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