CARD16

Gene Symbol CARD16
Entrez Gene 114769
Alt Symbol COP, COP1, PSEUDO-ICE
Species Human
Gene Type protein-coding
Description caspase recruitment domain family, member 16
Other Description CARD only domain-containing protein 1|CARD only protein|CARD-only protein 1|caspase recruitment domain-containing protein 16|caspase recruitment domain-only protein 1|caspase-1 dominant-negative inhibitor pseudo-ICE|caspase-1 inhibitor COP|pseudo interleukin-1 beta converting enzyme|pseudo interleukin-1beta converting enzyme|pseudo-IL1B-converting enzyme
Swissprots Q5EG05 Q96RJ9
Accessions EAW67062 Q5EG05 AF367017 AAK71682 AK125640 AK311902 BAG34843 AY885669 AAW78563 BC033638 BC070196 BC104635 BC117478 AAI17479 BC117480 AAI17481 BC141473 AAI41474 BC148760 AAI48761 XM_011542583 XP_011540885 NM_001017534 NP_001017534 NM_052889 NP_443121
Function Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. {ECO:0000269|PubMed:11432859, ECO:0000269|PubMed:11536016, ECO:0000269|PubMed:16920334}.
Tissue Specificity Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus. {ECO:0000269|PubMed:11432859, ECO:0000269|PubMed:11536016}.

COP1 293T Cell Transient Overexpression Lysate(Denatured) - H00114769-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

CARD16 overexpression lysate - LY409399 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

CARD16 overexpression lysate - LY422744 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

CARD16 293 Cell Lysate - 404958 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

CARD16 293 Cell Lysate - 409782 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

COP Overexpression Lysate (Denatured) - H00114769-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
COP1 transfected lysate.

COP Overexpression Lysate (Native) - NBL1-09376 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

CARD16 Over-expression Lysate Product - GWB-F9A079 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

CARD16 Over-expression Lysate Product - GWB-F13CE1 from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

COP Overexpression Lysate (Native) - NBP2-11021 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: COP Overexpression Lysate (Adult Normal) [NBP2-11021] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for COP.

Panoply™ Human CARD16 Knockdown Stable Cell Line - CSC-DC002368 from Creative biogene

Category Cell Line
Species Human
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