CARD16
| Gene Symbol | CARD16 |
|---|---|
| Entrez Gene | 114769 |
| Alt Symbol | COP, COP1, PSEUDO-ICE |
| Species | Human |
| Gene Type | protein-coding |
| Description | caspase recruitment domain family, member 16 |
| Other Description | CARD only domain-containing protein 1|CARD only protein|CARD-only protein 1|caspase recruitment domain-containing protein 16|caspase recruitment domain-only protein 1|caspase-1 dominant-negative inhibitor pseudo-ICE|caspase-1 inhibitor COP|pseudo interleukin-1 beta converting enzyme|pseudo interleukin-1beta converting enzyme|pseudo-IL1B-converting enzyme |
| Swissprots | Q5EG05 Q96RJ9 |
| Accessions | EAW67062 Q5EG05 AF367017 AAK71682 AK125640 AK311902 BAG34843 AY885669 AAW78563 BC033638 BC070196 BC104635 BC117478 AAI17479 BC117480 AAI17481 BC141473 AAI41474 BC148760 AAI48761 XM_011542583 XP_011540885 NM_001017534 NP_001017534 NM_052889 NP_443121 |
| Function | Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. {ECO:0000269|PubMed:11432859, ECO:0000269|PubMed:11536016, ECO:0000269|PubMed:16920334}. |
| Tissue Specificity | Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus. {ECO:0000269|PubMed:11432859, ECO:0000269|PubMed:11536016}. |
COP CRISPR/Cas9 KO Plasmid (h) - sc-416744 from Santa Cruz Biotechnology
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COP HDR Plasmid (h) - sc-416744-HDR from Santa Cruz Biotechnology
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COP Double Nickase Plasmid (h) - sc-416744-NIC from Santa Cruz Biotechnology
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COP Double Nickase Plasmid (h2) - sc-416744-NIC-2 from Santa Cruz Biotechnology
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COP CRISPR Activation Plasmid (h) - sc-416744-ACT from Santa Cruz Biotechnology
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COP CRISPR Activation Plasmid (h2) - sc-416744-ACT-2 from Santa Cruz Biotechnology
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COP Lentiviral Activation Particles (h) - sc-416744-LAC from Santa Cruz Biotechnology
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COP Lentiviral Activation Particles (h2) - sc-416744-LAC-2 from Santa Cruz Biotechnology
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COP siRNA (h) - sc-105233 from Santa Cruz Biotechnology
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COP shRNA Plasmid (h) - sc-105233-SH from Santa Cruz Biotechnology
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COP shRNA (h) Lentiviral Particles - sc-105233-V from Santa Cruz Biotechnology
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COP RNAi - H00114769-R02 from Novus Biologicals
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MISSION® esiRNA - EHU219981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5364 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5364 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03660 from Sigma-Aldrich
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CARD16 siRNA (Human) - CRJ4364 from Cohesion Biosciences
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COP RNAi - H00114769-R01 from Novus Biologicals
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CARD16 - MBS8221007 from MyBioSource
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shRNA set against Human CARD16 (NM_052889.2) - SHH254701 from Creative biogene
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shRNA set against Human COP1(NM_001017534.1) - SHG192385 from Creative biogene
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shRNA set against Human COP1(NM_052889.2) - SHG192403 from Creative biogene
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Human CARD16 siRNA - orb274865 from Biorbyt
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CARD16 shRNA Plasmid (Human) - CHJ4364 from Cohesion Biosciences
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CARD16 miRNA 3'UTR clone - MiUTR1H-02350 from Creative biogene
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