| Gene Symbol |
CARD16
|
| Entrez Gene |
114769
|
| Alt Symbol |
COP, COP1, PSEUDO-ICE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
caspase recruitment domain family, member 16
|
| Other Description |
CARD only domain-containing protein 1|CARD only protein|CARD-only protein 1|caspase recruitment domain-containing protein 16|caspase recruitment domain-only protein 1|caspase-1 dominant-negative inhibitor pseudo-ICE|caspase-1 inhibitor COP|pseudo interleukin-1 beta converting enzyme|pseudo interleukin-1beta converting enzyme|pseudo-IL1B-converting enzyme
|
| Swissprots |
Q5EG05 Q96RJ9
|
| Accessions |
EAW67062 Q5EG05 AF367017 AAK71682 AK125640 AK311902 BAG34843 AY885669 AAW78563 BC033638 BC070196 BC104635 BC117478 AAI17479 BC117480 AAI17481 BC141473 AAI41474 BC148760 AAI48761 XM_011542583 XP_011540885 NM_001017534 NP_001017534 NM_052889 NP_443121
|
| Function |
Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. {ECO:0000269|PubMed:11432859, ECO:0000269|PubMed:11536016, ECO:0000269|PubMed:16920334}.
|
| Tissue Specificity |
Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus. {ECO:0000269|PubMed:11432859, ECO:0000269|PubMed:11536016}.
|