EXT1

Gene Symbol	EXT1
Entrez Gene	2131
Alt Symbol	EXT, LGCR, LGS, TRPS2, TTV
Species	Human
Gene Type	protein-coding
Description	exostosin glycosyltransferase 1
Other Description	Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase\|Langer-Giedion syndrome chromosome region\|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase\|exostoses (multiple) 1\|exostosin 1\|exostosin-1\|glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase\|multiple exostoses protein 1\|putative tumor suppressor protein EXT1
Swissprots	Q16394 B2R7V2 Q9BVI9
Accessions	AAC51154 ADI56520 AGT15863 AGV77097 AHB20150 EAW91972 Q16394 AK130054 AK313129 BAG35949 BC001174 AAH01174 DQ891868 ABM82794 DQ895056 ABM85982 S79639 AAB62283 NM_000127 NP_000118
Function	Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. {ECO:0000269\|PubMed:11518722}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269\|PubMed:10679296}. Golgi apparatus membrane {ECO:0000269\|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269\|PubMed:10679296}. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus.
Tissue Specificity	Ubiquitous.
Top Pathways	Glycosaminoglycan biosynthesis - heparan sulfate / heparin

EXT1 (H-114) - sc-292430 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

EXT1 (N-16) - sc-11039 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

EXT1 (N-16): sc-11039. Immunoperoxidase staining of formalin fixed, paraffin-embedded human rectum tissue showing cytoplasmic and membrane staining of glandular cells.

EXT1 (V-15) - sc-11040 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-Ext1 antibody - ab126305 from Abcam

Prices	$443.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Ext1 antibody (ab126305) at 1/100 dilutionLane 1 : Negative control (vector only transfected HEK293T lysate)Lane 2 : Over-expression lysate (co-expressed with C-terminal myc-DDK tag (~3.1kDa) in HEK293T cells

Anti-Ext1 antibody - C-terminal - ab187309 from Abcam

Host	Rabbit
Clonality	Polyclonal

Anti-Ext1 antibody - C-terminal (ab187309) at 1/1000 dilution + Jurkat cell lysate

Anti-Ext1 antibody - N-terminal - ab187306 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Ext1 antibody - N-terminal (ab187306) at 1/1000 dilutionLane 1 : HeLa total cell extractLane 2 : Jurkat total cell extract

Anti-EXT1 Antibody (aa660-676) - LS-C3044 from LifeSpan Bioscience

Prices	$265.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-EXT1 Antibody (aa74-90) - LS-C3043 from LifeSpan Bioscience

Prices	$265.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-EXT1 Antibody - LS-C192766 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-EXT1 Antibody (aa297-326, APC) - LS-C214062 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EXT1 Antibody (aa297-326, Biotin) - LS-C214063 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EXT1 Antibody (aa297-326, Azide-free, HRP) - LS-C214065 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EXT1 Antibody (aa297-326, FITC) - LS-C214064 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EXT1 Antibody (aa297-326, PE) - LS-C214066 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EXT1 Antibody (clone 5A5) - LS-C197171 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	5A5

Detection limit for recombinant GST tagged EXT1 is approximately 3 ng/ml as a capture antibody.

Anti-EXT1 Antibody (aa298-326) - LS-C167864 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

EXT1 Antibody western blot of K562 cell line lysates (35 ug/lane). The EXT1 antibody detected the EXT1 protein (arrow).

Anti-EXT1 Antibody (aa334-549, Biotin) - LS-C298501 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-EXT1 Antibody (aa334-549, FITC) - LS-C305155 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-EXT1 Antibody - LS-C310297 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-EXT1 Antibody (aa486-717) - LS-C311524 from LifeSpan Bioscience

Prices	$250.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EXT1 Antibody (aa1-199) - LS-C311780 from LifeSpan Bioscience

Prices	$250.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EXT1 Antibody (aa297-326) - LS-C321230 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EXT1 Antibody (aa334-549) - LS-C293799 from LifeSpan Bioscience

Prices	$405.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-EXT1 Antibody - LS-C331833 from LifeSpan Bioscience

Prices	$255.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of paraffin-embedded human esophageal cancer using EXT1 antibody at dilution of 1:100 (400x lens).

Anti-EXT1 Antibody (aa297-326, AP) - LS-C214061 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

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