EXT1

Gene Symbol	EXT1
Entrez Gene	2131
Alt Symbol	EXT, LGCR, LGS, TRPS2, TTV
Species	Human
Gene Type	protein-coding
Description	exostosin glycosyltransferase 1
Other Description	Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase|Langer-Giedion syndrome chromosome region|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase|exostoses (multiple) 1|exostosin 1|exostosin-1|glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase|multiple exostoses protein 1|putative tumor suppressor protein EXT1
Swissprots	Q16394 B2R7V2 Q9BVI9
Accessions	AAC51154 ADI56520 AGT15863 AGV77097 AHB20150 EAW91972 Q16394 AK130054 AK313129 BAG35949 BC001174 AAH01174 DQ891868 ABM82794 DQ895056 ABM85982 S79639 AAB62283 NM_000127 NP_000118
Function	Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. {ECO:0000269|PubMed:11518722}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Golgi apparatus membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus.
Tissue Specificity	Ubiquitous.
Top Pathways	Glycosaminoglycan biosynthesis - heparan sulfate / heparin

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Ext1 protein (His-DHFR tag) - ab127438 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

EXT1 Antibody Blocking Peptide - LS-E4506 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Exostosin 1 Partial Recombinant Protein - H00002131-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Exostosin 1 Partial Recombinant Protein - H00002134-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Exostosin 1 Recombinant Protein - H00002131-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

EXT1-Antibody-Center-Blocking-Peptide - BP16833c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EXT1-Antibody-C-term-Blocking-Peptide - BP18003b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Exostosin 1, CF - 8379-GT-010 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Asp69-Leu746 with a C-terminal 6-His tag

Recombinant Human Exostosin 1/2 Heterodimer, CF - 8567-GT-020 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Arg29-Leu746 with a C-terminal 2-His and HA tag (EXT1) & Ser53-Leu718 with a C-terminal 6-His tag (EXT2)

EXT1 Blocking Peptide - 33R-4777 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EXT1 Blocking Peptide - 33R-3726 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human Exostoses 1 Protein - abx066473 from Abbexa Category Protein Source E.coli Species Human

Exostosin-1 - H00002131-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

Exostosin-1 - H00002131-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Exostosin-1 - H00002131-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

Exostosin-1 - H00002131-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Exostosin-1 - H00002131-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Exostoses 1 (EXT1), Human - 20-9146 from ARP American Research Products Category Protein Prices $485.00 Sizes 50 µg Source E.coli Species Human

EXT1 fusion protein - ag0171 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Exostosin-1 Peptide - 350499 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

Recombinant Exostoses 1 (EXT1) - RPG239Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Exostoses 1 (EXT1) - RPG239Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant B-Cell CLL/Lymphoma 9 (Bcl9) - RPE585Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Exostosin-1(EXT1) - CSB-YP620959HU CSB-EP620959HU CSB-BP620959HU CSB-MP620959HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Exostosin 1 Protein, CF - 8379-GT from R&D Systems Category Protein Prices $349.00 Sizes 10 µg Source Chinese Hamster Ovary cell line, CHO-derived Asp69-Leu746 with a C-terminal 6-His tag Species Human

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