EXT1

Gene Symbol EXT1
Entrez Gene 2131
Alt Symbol EXT, LGCR, LGS, TRPS2, TTV
Species Human
Gene Type protein-coding
Description exostosin glycosyltransferase 1
Other Description Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase|Langer-Giedion syndrome chromosome region|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase|exostoses (multiple) 1|exostosin 1|exostosin-1|glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase|multiple exostoses protein 1|putative tumor suppressor protein EXT1
Swissprots Q16394 B2R7V2 Q9BVI9
Accessions AAC51154 ADI56520 AGT15863 AGV77097 AHB20150 EAW91972 Q16394 AK130054 AK313129 BAG35949 BC001174 AAH01174 DQ891868 ABM82794 DQ895056 ABM85982 S79639 AAB62283 NM_000127 NP_000118
Function Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. {ECO:0000269|PubMed:11518722}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Golgi apparatus membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus.
Tissue Specificity Ubiquitous.
Top Pathways Glycosaminoglycan biosynthesis - heparan sulfate / heparin

Human-EXT1-cDNA-Clone - DC00553 from Abgent, a WuXi AppTec company

Prices $1,007.10
Sizes 10 µg
Species Human
Accession BC001174

EXT1 - MBS1267455 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC001174

Human EXT1 ORF clone (NM_000127.2) - CDCR061958 from Creative biogene

Species Human

Human EXT1 ORF Clone (BC001174) - CDCS405442 from Creative biogene

Species Human
Accession Q16394

Human EXT1 ORF clone (BC001174) - CDCB159199 from Creative biogene

Species Human

Human EXT1 cDNA Clone(NM_000127.2) - CDFH006219 from Creative biogene

Species Human

Human EXT1 cDNA Clone(NM_000127.2) - CDFH006220 from Creative biogene

Species Human
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