EXT1

Gene Symbol	EXT1
Entrez Gene	2131
Alt Symbol	EXT, LGCR, LGS, TRPS2, TTV
Species	Human
Gene Type	protein-coding
Description	exostosin glycosyltransferase 1
Other Description	Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase|Langer-Giedion syndrome chromosome region|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase|exostoses (multiple) 1|exostosin 1|exostosin-1|glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase|multiple exostoses protein 1|putative tumor suppressor protein EXT1
Swissprots	Q16394 B2R7V2 Q9BVI9
Accessions	AAC51154 ADI56520 AGT15863 AGV77097 AHB20150 EAW91972 Q16394 AK130054 AK313129 BAG35949 BC001174 AAH01174 DQ891868 ABM82794 DQ895056 ABM85982 S79639 AAB62283 NM_000127 NP_000118
Function	Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. {ECO:0000269|PubMed:11518722}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Golgi apparatus membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus.
Tissue Specificity	Ubiquitous.
Top Pathways	Glycosaminoglycan biosynthesis - heparan sulfate / heparin

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-EXT1-cDNA-Clone - DC00553 from Abgent, a WuXi AppTec company Prices $1,007.10 Sizes 10 µg Species Human Accession BC001174

EXT1 - MBS1267455 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC001174

Human EXT1 ORF clone (NM_000127.2) - CDCR061958 from Creative biogene Species Human

Human EXT1 ORF Clone (BC001174) - CDCS405442 from Creative biogene Species Human Accession Q16394

Human EXT1 ORF clone (BC001174) - CDCB159199 from Creative biogene Species Human

Human EXT1 cDNA Clone(NM_000127.2) - CDFH006219 from Creative biogene Species Human

Human EXT1 cDNA Clone(NM_000127.2) - CDFH006220 from Creative biogene Species Human

Human EXT1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14304-NM from Sino Biological Species Human

Human EXT1 Gene ORF cDNA clone expression plasmid - HG14304-UT from Sino Biological Species Human

Human EXT1 Gene ORF cDNA clone expression plasmid, N-His tag - HG14304-NH from Sino Biological Species Human

Human EXT1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14304-ACR from Sino Biological Species Human

Human EXT1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14304-CM from Sino Biological Species Human

Human EXT1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG14304-CY from Sino Biological Species Human

Human EXT1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG14304-NY from Sino Biological Species Human

Human EXT1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14304-G-F from Sino Biological Species Human

Human EXT1 Gene ORF cDNA clone expression plasmid, C-His tag - HG14304-CH from Sino Biological Species Human

Human EXT1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14304-NF from Sino Biological Species Human

Human EXT1 Gene ORF cDNA clone in cloning vector - HG14304-G from Sino Biological Species Human

Human EXT1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14304-ACG from Sino Biological Species Human

Human EXT1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14304-CF from Sino Biological Species Human

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