EXT1

Gene Symbol EXT1
Entrez Gene 2131
Alt Symbol EXT, LGCR, LGS, TRPS2, TTV
Species Human
Gene Type protein-coding
Description exostosin glycosyltransferase 1
Other Description Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase|Langer-Giedion syndrome chromosome region|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase|exostoses (multiple) 1|exostosin 1|exostosin-1|glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase|multiple exostoses protein 1|putative tumor suppressor protein EXT1
Swissprots Q16394 B2R7V2 Q9BVI9
Accessions AAC51154 ADI56520 AGT15863 AGV77097 AHB20150 EAW91972 Q16394 AK130054 AK313129 BAG35949 BC001174 AAH01174 DQ891868 ABM82794 DQ895056 ABM85982 S79639 AAB62283 NM_000127 NP_000118
Function Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. {ECO:0000269|PubMed:11518722}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Golgi apparatus membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus.
Tissue Specificity Ubiquitous.
Top Pathways Glycosaminoglycan biosynthesis - heparan sulfate / heparin

EXT1 CRISPR/Cas9 KO Plasmid (h) - sc-404635 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXT1 HDR Plasmid (h) - sc-404635-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXT1 Double Nickase Plasmid (h) - sc-404635-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXT1 Double Nickase Plasmid (h2) - sc-404635-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXT1 CRISPR Activation Plasmid (h) - sc-404635-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXT1 CRISPR Activation Plasmid (h2) - sc-404635-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXT1 Lentiviral Activation Particles (h) - sc-404635-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXT1 Lentiviral Activation Particles (h2) - sc-404635-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EXT1 siRNA (h) - sc-106792 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EXT1 shRNA Plasmid (h) - sc-106792-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EXT1 shRNA (h) Lentiviral Particles - sc-106792-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Exostosin 1 RNAi - H00002131-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU007581 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8056 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8056 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02692 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02692

EXT1 siRNA (Human) - CRH1482 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Exostosin 1 RNAi - H00002134-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

EXT1 - MBS8214106 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human EXT1 (NM_000127.2) - SHH288209 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human EXT1(NM_000127.2) - SHH042455 from Creative biogene

Category siRNA
Species Reactivities Human

EXT1 shRNA Plasmid (Human) - CHH1482 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EXT1 miRNA 3'UTR clone - MiUTR1H-03352 from Creative biogene

Species Reactivities Human
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