IRF9

Gene Symbol	IRF9
Entrez Gene	10379
Alt Symbol	IRF-9, ISGF3, ISGF3G, p48
Species	Human
Gene Type	protein-coding
Description	interferon regulatory factor 9
Other Description	IFN-alpha-responsive transcription factor subunit\|ISGF-3 gamma\|ISGF3 p48 subunit\|interferon-stimulated gene factor 3 gamma\|interferon-stimulated transcription factor 3, gamma (48kD)\|interferon-stimulated transcription factor 3, gamma 48kDa\|transcriptional regulator ISGF3 subunit gamma
Swissprots	D3DS61 Q00978
Accessions	EAW66092 EAW66093 EAW66094 Q00978 AK295467 BAG58398 AK308347 BC035716 AAH35716 BI497082 BI919023 EU446692 ABZ92221 M87503 AAA58687 U92994 NM_006084 NP_006075
Function	Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:11846981}. Nucleus {ECO:0000269\|PubMed:11846981}. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
Top Pathways	Jak-STAT signaling pathway, Hepatitis C, Osteoclast differentiation, Measles, Influenza A

ISGF-3γ p48 (H-10) - sc-365893 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

ISGF-3γ p48 (H-10): sc-365893. Western blot analysis of ISGF-3γ p48 expression in MCF7 whole cell lysate.

ISGF-3γ p48 (C-20) - sc-496 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

ISGF-3γ p48 (C-20): sc-496. Western blot analysis of ISGF-3γ p48 expression in non-transfected: sc-117752 (A) and human ISGF-3γ p48 transfected: sc-115734 (B) 293T whole cell lysates.

ISGF-3γ p48 (H-143) - sc-10793 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

ISGF-3γ p48 (H-143): sc-10793. Western blot analysis of ISGF-3γ p48 expression in HeLa + IFN-α whole cell lysate.

ISGF-3γ p48 (6) - sc-135953 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/0.5 ml
Host	Mouse
Clonality	Monoclonal

ISGF-3γ p48 (6): sc-135953. Western blot analysis of ISGF-3γ p48 expression in human endothelial whole cell lysate.

Anti-Interferon regulatory factor 9 antibody - ab51639 from Abcam

Prices	$385.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Interferon regulatory factor 9 antibody (ab51639) at 1 µg/ml + HepG2 cell lysate at 15 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Interferon regulatory factor 9 antibody - ab126940 from Abcam

Prices	$384.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Interferon regulatory factor 9 antibody (ab126940) at 1/5000 dilutionLane 1 : A549 whole cell lysateLane 2 : HeLa whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Interferon regulatory factor 9 antibody - ab118189 from Abcam

Prices	$378.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Interferon regulatory factor 9 antibody (ab118189) at 1/500 dilution + K562 cell lysate

Anti-Interferon regulatory factor 9 antibody - ab56583 from Abcam

Host	Mouse
Clonality	Monoclonal

TF IRF9 antibody (ab56583) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human prostate.

Anti-Interferon regulatory factor 9 antibody - ab56677 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

TF IRF9 antibody (ab56677) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human malignant lymphoma, diffuse large B tissue.

Anti-Interferon regulatory factor 9 antibody [EPR3939] - ab109309 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR3939

All lanes : Anti-Interferon regulatory factor 9 antibody [EPR3939] (ab109309) at 1/1000 dilutionLane 1 : K562 treated with IFN-alpha cell lysatesLane 2 : K562 cell lysatesLane 3 : HeLa treated with IFN-alpha cell lysatesLane 4 : HeLa cell lysatesLane 5 : Jurkat cell lysatesLysates/proteins at 10 µg per lane.

Anti-ISGF3 / IRF9 Antibody - LS-C155416 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

IHC of paraffin-embedded Breast ca, using IRF9 antibody at 1:250 dilution.

Anti-ISGF3 / IRF9 Antibody (Internal, clone EPR3939) IHC-plus™ - LS-B11318 from LifeSpan Bioscience

Prices	$395.00
Sizes	50 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR3939

Anti-ISGF3 / IRF9 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ISGF3 / IRF9 Antibody (aa238-393) - LS-C125793 from LifeSpan Bioscience

Prices	$605.00
Sizes	100 µg
Host	Sheep
Clonality	Polyclonal

Anti-ISGF3 / IRF9 Antibody (aa82-112, APC) - LS-C260376 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ISGF3 / IRF9 Antibody (aa82-112, AP) - LS-C260377 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ISGF3 / IRF9 Antibody (aa82-112, Biotin) - LS-C260378 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ISGF3 / IRF9 Antibody (aa41-90) - LS-C29666 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ISGF3 / IRF9 Antibody (aa82-112, FITC) - LS-C260379 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ISGF3 / IRF9 Antibody (aa82-112, Azide-free, HRP) - LS-C260382 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ISGF3 / IRF9 Antibody (aa82-112, PE) - LS-C260384 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ISGF3 / IRF9 Antibody - LS-C308503 from LifeSpan Bioscience

Prices	$455.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-ISGF3 / IRF9 Antibody - LS-C311298 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ISGF3 / IRF9 Antibody - LS-C311300 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ISGF3 / IRF9 Antibody (aa1-394, Azide-free) - LS-C327641 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal

Anti-ISGF3 / IRF9 Antibody (clone 1D11) - LS-C105099 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1D11

ISGF3G monoclonal antibody (M02), clone 1D11 Western blot of ISGF3G expression in MCF-7.

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