| Gene Symbol |
IRF9
|
| Entrez Gene |
10379
|
| Alt Symbol |
IRF-9, ISGF3, ISGF3G, p48
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interferon regulatory factor 9
|
| Other Description |
IFN-alpha-responsive transcription factor subunit|ISGF-3 gamma|ISGF3 p48 subunit|interferon-stimulated gene factor 3 gamma|interferon-stimulated transcription factor 3, gamma (48kD)|interferon-stimulated transcription factor 3, gamma 48kDa|transcriptional regulator ISGF3 subunit gamma
|
| Swissprots |
D3DS61 Q00978
|
| Accessions |
EAW66092 EAW66093 EAW66094 Q00978 AK295467 BAG58398 AK308347 BC035716 AAH35716 BI497082 BI919023 EU446692 ABZ92221 M87503 AAA58687 U92994 NM_006084 NP_006075
|
| Function |
Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11846981}. Nucleus {ECO:0000269|PubMed:11846981}. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
|
| Top Pathways |
Jak-STAT signaling pathway, Hepatitis C, Osteoclast differentiation, Measles, Influenza A
|