IRF9

Gene Symbol IRF9
Entrez Gene 10379
Alt Symbol IRF-9, ISGF3, ISGF3G, p48
Species Human
Gene Type protein-coding
Description interferon regulatory factor 9
Other Description IFN-alpha-responsive transcription factor subunit|ISGF-3 gamma|ISGF3 p48 subunit|interferon-stimulated gene factor 3 gamma|interferon-stimulated transcription factor 3, gamma (48kD)|interferon-stimulated transcription factor 3, gamma 48kDa|transcriptional regulator ISGF3 subunit gamma
Swissprots D3DS61 Q00978
Accessions EAW66092 EAW66093 EAW66094 Q00978 AK295467 BAG58398 AK308347 BC035716 AAH35716 BI497082 BI919023 EU446692 ABZ92221 M87503 AAA58687 U92994 NM_006084 NP_006075
Function Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11846981}. Nucleus {ECO:0000269|PubMed:11846981}. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
Top Pathways Jak-STAT signaling pathway, Hepatitis C, Osteoclast differentiation, Measles, Influenza A

ISGF-3γ p48 CRISPR/Cas9 KO Plasmid (h) - sc-400958 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ISGF-3γ p48 HDR Plasmid (h) - sc-400958-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ISGF-3γ p48 Double Nickase Plasmid (h) - sc-400958-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ISGF-3γ p48 Double Nickase Plasmid (h2) - sc-400958-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ISGF-3γ p48 CRISPR Activation Plasmid (h) - sc-400958-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ISGF-3γ p48 CRISPR Activation Plasmid (h2) - sc-400958-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ISGF-3γ p48 Lentiviral Activation Particles (h) - sc-400958-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ISGF-3γ p48 Lentiviral Activation Particles (h2) - sc-400958-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ISGF-3γ p48 siRNA (h) - sc-38013 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ISGF-3γ p48 shRNA Plasmid (h) - sc-38013-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ISGF-3γ p48 shRNA (h) Lentiviral Particles - sc-38013-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IRF9 RNAi - H00010379-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU226031 from Sigma-Aldrich

Category siRNA
Prices $140.00, $140.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10770 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10770 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03490 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03490

IRF9 siRNA (Human) - CRH7030 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IRF9 - MBS8228557 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human IRF9 (NM_006084.4) - SHH320677 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ISGF3G(NM_006084.4) - SHL181034 from Creative biogene

Category siRNA
Species Reactivities Human

IRF9 shRNA Plasmid (Human) - CHH7030 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

IRF9 miRNA 3'UTR clone - MiUTR1H-05009 from Creative biogene

Species Reactivities Human
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